NDLI: Biological rhythms: Circadian clocks limited by noise

Content Provider	Semantic Scholar
Author	Barkai, Naama Leibler, Stanislas
Copyright Year	2000
Abstract	Circadian rhythms, which provide internal daily periodicity, are used by a wide range of organisms to anticipate daily changes in the environment. It seems that these organisms generate circadian periodicity by similar biochemical networks within a single cell. A model based on the common features of these biochemical networks shows that a circadian network can oscillate reliably in the presence of stochastic biochemical noise and when cellular conditions are altered. We propose that the ability to resist such perturbations imposes strict constraints on the oscillation mechanisms underlying circadian periodicity in vivo.
Starting Page	267
Ending Page	268
Page Count	2
File Format	PDF HTM / HTML
DOI	10.1038/35002258
PubMed reference number	10659837
Journal	Medline
Volume Number	403
Alternate Webpage(s)	http://www.math.rutgers.edu/~sontag/sysbio_papers_readings/barkai_leibler_circadian00.pdf
Alternate Webpage(s)	http://sites.math.rutgers.edu/~sontag/sysbio_papers_readings/barkai_leibler_circadian00.pdf
Alternate Webpage(s)	https://doi.org/10.1038/35002258
Journal	Nature
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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