Serum iron levels and response to hepatitis B virus.

Content Provider	Semantic Scholar
Author	Felton, Capt. Lustbader, Edward D. Merten, Cynthia Blumberg, Baruch S.
Copyright Year	1979
Abstract	Response to hepatitis B virus (HBV) infection [HBV surface antigen (HBsAg) and antibody to HBsAg (anti-HBs)], serum iron, total iron-binding capacity, hematological status (erythrocytes, Hb, and hematocrit), and evidence of liver damage (serum glutamic pyruvic transaminase; aspartate aminotransferase, L-aspartate:2-oxoglutarate aminotransferase, EC 2.6.1.1) were determined for 201 patients on chronic renal dialysis. Four factors-serum iron level, transminase level, sex, and HBV response [i.e., infected-HBsAg(+) (HBsAg positive), anti-HBs(+) (anti-HBs positive), or no response]-were analyzed simultaneously to test the hypothesis that serum iron is higher in those with HBsAg in their serum than in those without HBsAg, independent of the transaminase level. Four independent, statistically significant two-factor interactions were identified. (i) Serum iron is higher in those HBsAg(+). (ii) Serum iron is higher in those with increased transaminase. (iii) Transaminase is higher in those HBsAg(+). (iv) Males are more likely to be HbsAg(+) and females are more likely to be anti-HBs(+). Also, those who are HBsAg(+) have significantly higher percent iron saturation (serum iron/total iron-binding capacity). That is, the hypothesis was supported by the findings. Several additional biological hypotheses are suggested, including a possible role of increased iron levels in susceptibility and response to HBV infection and the possible relationship between higher iron levels and the likelihood of HBV infection progressing to primary hepatocellular carcinoma. In addition, further tests of the initial hypothesis in nonhospitalized populations with endemic HBV infection are proposed.
Starting Page	49
Ending Page	58
Page Count	10
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.pnas.org/content/76/5/2438.full.pdf
PubMed reference number	287082v1
Volume Number	76
Issue Number	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Subject Keyword	Alanine Transaminase Aspartate Transaminase Aspartic Acid Bronchioloalveolar Adenocarcinoma Chemical and Drug Induced Liver Injury Dialysis procedure Hepatitis B Surface Antigens Hepatitis B Virus Surface Antibody Herpesvirus 1, Cercopithecine Iron measurement Liver and Intrahepatic Biliary Tract Carcinoma Liver carcinoma Patients Transaminases Transferrin saturation measurement
Content Type	Text
Resource Type	Article