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EPA releases mercury report. Environmental Protection Agency.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Saunders, Nick Paterson, Michael E. L. Sherriff Epenetos, Agamemnon A. |
| Copyright Year | 1998 |
| Abstract | We would suggest that this effect of stasis and nodal enlargement should be borne in mind when interpreting antibody guided scans. Que-reste-t-il de la lymphographie dans les carcinomes operables du col uteri? Bull. Sir-Thank you for bringing to our attention the letter of Saunders et al. in which it is stated that non-specific antibody binding in the pelvic lymph nodes may be partly explained by the presence of X-ray contrast medium in the lymphatics. Certainly their studies of using a polyclonal anti CEA antibody linked to iodine-131 concurrently with bipedal X-ray lymphangiography demonstrate that lipid-soluble contrast medium can interfere with antibody localisation as shown by their illustrated example. We agree therefore with them that X-ray contrast medium can be a further factor in non-specific antibody capture by lymphatics. Since our last report on antibody guided lymphangiography (Epenetos, 1985) we have performed further lymphangiography but on this occasion administering radiolabelled antibody subcutaneously without injection of contrast. We have seen again non-specific antibody capture by lymphatics but our data so far would indicate that this capture is less than when the antibody was injected during lymphangiography, pointing again to the fact that X-ray contrast medium interferes with radio-immunolocalisation. We also noted that the use of indium-labelled monoclonal antibodies given subcutaneously causes more marked imaging of local lymphatics as compared to iodinated antibody. This is probably due to the different kinetics of the various radiolabels after antibody breakdown. We still believe that the best way to sort out specific and non-specific binding is to perform immuno-lymphangiography using a specific antibody followed by a non-specific antibody. Yours etc., Reference EPENETOS, A.A. (1985). Antibody guided lymphangio-graphy in the staging of cervical cancer. |
| Starting Page | A56 |
| Ending Page | A56 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 10408935 |
| Volume Number | 106 |
| Journal | Environmental health perspectives |
| Alternate Webpage(s) | http://ftp.ncbi.nlm.nih.gov/pub/pmc/d7/a5/envhper00525-0014a-color.PMC1533020.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Environmental Illness United States Environmental Protection Agency |
| Content Type | Text |
| Resource Type | Article |
