Palladium C–N bond formation catalysed by air-stable robust polydentate ferrocenylphosphines: a comparative study for the efficient and selective coupling of aniline derivatives to dichloroarene

Content Provider	Semantic Scholar
Author	Platon, Mélanie Roger, Julien Royer, Sylviane Hierso, Jean-Cyrille
Copyright Year	2014
Abstract	The arylation of aniline derivatives with dichloroarenes under a low palladium content (below the currently used 5 to 10 mol%) was studied using nine different ferrocenylphosphine ligands, including the easily accessible 1,1′-bis(diphenylphosphino)ferrocene, DPPF. The electron-enriched air-stable tridentate ferrocenylpolyphosphine 1,2-bis(diphenylphosphino)-1′-(diisopropylphosphino)-4-tert-butylferrocene, L5, employed in 2 mol% in combination with 1 mol% [PdCl(η3-C3H5)]2 allows an efficient and selective coupling, while such demanding substrates currently induce chloroarene homocoupling and/or dehalogenation processes. The scope and limitation of the optimized system are explored, with a focus on electron-poor fluoroanilines (deactivated nucleophiles) and electron-rich methylated and methoxylated dichlorobenzenes (deactivated electrophiles).
Starting Page	2072
Ending Page	2080
Page Count	9
File Format	PDF HTM / HTML
DOI	10.1039/C4CY00151F
Volume Number	4
Alternate Webpage(s)	http://www.rsc.org/suppdata/cy/c4/c4cy00151f/c4cy00151f1.pdf
Alternate Webpage(s)	https://doi.org/10.1039/C4CY00151F
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article