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One –Pot Synthesis of Polyhydroquinoline Derivatives via Hantzsch Condensation Reaction Using Nanosized Magnesium Oxide as Heterogeneous Catalyst
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mirzaee, Hakimeh Izadyar, Ahmad Davoodnia, A. Eshghi, Hoseyn |
| Copyright Year | 2014 |
| Abstract | An efficient, recyclable and environmental-friendly synthetic route to polyhdroquinoline derivatives have been developed via multi-component one-pot Hantzsch reaction of various aromatic aldehyde, 2 equivalents of 5,5-dimethyl-1,3-cyclohexanedione (dimedone), ethyl acetoacetate and ammonium acetate using nano magnesium oxide as a catalyst in ethanol under reflux condition. Reaction with 4-chlorobenzaldehyde was selected as the model reaction and different conditions for temperature, amount of catalyst and kind of solvent have been studied on it. It was found that 0.03 g catalyst in reflux condition and ethanol as solvent is the optimum condition which resulted in 94% yield. The present approach offers several advantages such as short reaction times, easy isolation and purification of product, and safe, non-toxic, recyclable and economic use of catalyst. |
| Starting Page | 57 |
| Ending Page | 63 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Volume Number | 8 |
| Alternate Webpage(s) | http://journals.iau.ir/article_516108_3aeec90a124c7f4177582fca05dab43c.pdf |
| Alternate Webpage(s) | http://jacr.kiau.ac.ir/article_516108_3aeec90a124c7f4177582fca05dab43c.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
