Loading...
Please wait, while we are loading the content...
Similar Documents
Fluconazole–malonic acid (1/1)
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kastelic, Jože Kikelj, Danijel Leban, Ivan Lah, Nina |
| Copyright Year | 2013 |
| Abstract | Co-crystallizaton of the anti-fungal drug fluconazole [2-(2,4-difluoro-phen-yl)-1,3-bis-(1H-1,2,4-triazol-1-yl)propan-2-ol] with malonic acid in acetonitrile solution resulted in the formation of the title 1:1 co-crystal, C13H12F2N6O·C3H4O4. The geometry around the central fluconazole atom is distorted tetrahedral. The dihedral angles between the triazole rings and the fluorinated phenyl ring are 30.64 (7) and 61.91 (5)°. In the crystal, the basic packing motif may be envisioned as a cyclic aggregate formed of two fluconazole mol-ecules linked by two malonic acid mol-ecules through O-H⋯N and O-H⋯O hydrogen bonds. Such aggregates are further connected into (001) layers by further O-H⋯N hydrogen bonds. The structure also features weak non-classical C-H⋯O and C-H⋯N inter-actions. |
| Starting Page | o378 |
| Ending Page | o379 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://journals.iucr.org/e/issues/2013/03/00/gk2552/gk2552.pdf |
| PubMed reference number | 23476565 |
| Alternate Webpage(s) | https://doi.org/10.1107/S1600536813003656 |
| DOI | 10.1107/s1600536813003656 |
| Journal | Acta crystallographica. Section E, Structure reports online |
| Volume Number | 69 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | DUOXA1 gene Fluconazole Hy-Phen Protein Domain Ring device Triazoles acetonitrile anatomical layer malonic acid phenyl |
| Content Type | Text |
| Resource Type | Article |
