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Lansoprazole does not affect the bioavailability of oral contraceptives.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Fuchs, W. S. Sennewald, Regina Klotz, Ulrich |
| Copyright Year | 1994 |
| Abstract | The effects of the proton pump inhibitor lansoprazole on the bioavailability of a low-dose oral contraceptive (OC), containing 0.03 mg ethinyloestradiol (EE) and 0.15 mg levonorgestrel (LNG), were investigated. Twenty-four healthy females (aged 19-35 years; weight 60.6 +/- 7.1 kg) participated in a multiple-dose, placebo-controlled, randomized two-way cross-over study. All subjects received the OC over 2 full menstrual cycles from day 1 to day 21 separated by a drug-free interval of 7 days. Lansoprazole (60 mg day-1) or placebo was coadministered for 3 weeks each. Plasma concentrations of EE and LNG were determined by GC-MS. The 90% confidence intervals for ratios of Cmax and AUC after log transformation of both EE and LNG ranged between 91 and 111%, indicating that lansoprazole did not affect the bioavailability of EE and LNG. |
| File Format | PDF HTM / HTML |
| DOI | 10.1111/j.1365-2125.1994.tb04370.x |
| PubMed reference number | 7833230 |
| Journal | Medline |
| Volume Number | 38 |
| Issue Number | 4 |
| Alternate Webpage(s) | http://pubmedcentralcanada.ca/pmcc/articles/PMC1364784/pdf/brjclinpharm00016-0088.pdf |
| Alternate Webpage(s) | https://doi.org/10.1111/j.1365-2125.1994.tb04370.x |
| Journal | British journal of clinical pharmacology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
