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Calcitonin, calcitonin gene-related peptide, adrenomedullin and amylin: homologous peptides, separate receptors and overlapping biological actions.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Muff, Roman Born, Walter Fischer, Jan A. |
| Copyright Year | 1995 |
| Abstract | Calcitonin, calcitonin gene-related peptide, adrenomedullin and amylin are structurally related peptides with N-terminal 6-7 amino acid ring structures linked by a disulfide bridge and with amidated C-termini. Among the related bioactive peptides, the structures of the calcitonin receptor and subtypes thereof have been identified so far through molecular cloning. Cross-reaction between receptors of calcitonin, calcitonin gene-related peptide, adrenomedullin and amylin, as well as overlapping biological actions, anticipate that the respective receptors belong to a family of G-protein-coupled receptors that include those of parathyroid hormone, secretin and vasointestinal peptide. |
| Starting Page | 17 |
| Ending Page | 20 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1530/eje.0.1330017 |
| PubMed reference number | 7627335 |
| Journal | Medline |
| Volume Number | 133 |
| Issue Number | 1 |
| Alternate Webpage(s) | https://eje.bioscientifica.com/downloadpdf/journals/eje/133/1/eje_133_1_002.pdf |
| Journal | European journal of endocrinology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |