NDLI: Antihyperglycemic and antioxidative effects of ethanolic leaf extract of Croton zambesicus in streptozotocin induced diabetic rats

Please wait, while we are loading the content...

Antihyperglycemic and antioxidative effects of ethanolic leaf extract of Croton zambesicus in streptozotocin induced diabetic rats

Content Provider	Semantic Scholar
Author	Ofusori, David A. Komolafe, Omobola Aderibigbe Adewole, O. S. Obuotor, Efere Fakunle, Julius Bayode
Copyright Year	2014
Abstract	The aim of this study was to evaluate the antihyperglycemic and antioxidative effect of Croton zambesicus (C. zambesicus) leaf extract in experimentally induced diabetic rats. Seventy adult male wistar rats were divided into seven groups (n=10). Group A, control rats; Group B, untreated diabetic rats; Group C, diabetic rats in which C. zambesicus therapy started 2 weeks prior to induction of diabetes; Group D and Group E, diabetic rats administered orally with C. zambesicus leaf extract for 2 and 4 weeks respectively; Group F, normal rats administered orally with C. zambesicus; Group G, diabetic rats administered glimepiride (2 mg/kg/day). The animals were weighed and sacrificed. Serum was obtained for catalase (CAT), glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx) and thiobarbituric acid reactive substances (TBARS) analyses using respective diagnostic kits. The result showed a better remediation with early commencement of the extract treatment. C. zambesicus exhibited significant (p<0.05) reduction in blood glucose level in the extract treated group when compared with other groups. The result also presented an improvement in the CAT, GSH, SOD, GPx and a reduction in TBARS in the extract treated groups as against a reduction in the antioxidant level and an increase in TBARS concentration in the untreated diabetic group.In conclusion, this study demonstrated that C. zambesicus leaf extract possesses antihyperglycemic and antioxidative activities in streptozotocin (STZ) induced diabetic rats and by extension may be useful in the management of diabetes mellitus.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://jcmb.halic.edu.tr/pdf/12-1_2/12-3.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in