Loading...
Please wait, while we are loading the content...
Similar Documents
Sex Moderates the Impact of Diagnosis and Amyloid PET Positivity on Hippocampal Subfield Volume
| Content Provider | Semantic Scholar |
|---|---|
| Author | Caldwell, Jessica Z. K. Berg, J. Shan, Guogen Cummings, Jeffrey L. Banks, Sarah J. |
| Copyright Year | 2018 |
| Abstract | We examined moderation effects of sex and diagnosis on the effect of positive florbetapir positron emission tomography (PET) amyloid-β (Aβ) scan (A+) on hippocampus subfield volumes in 526 normal control (NC) and early mild cognitive impairment (eMCI) participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI2; ADNI-GO). Regression moderation models showed that women- but not men- with NC designation did not show reduced subiculum volumes despite A+. At the eMCI stage, A+ was detrimental across sexes. Findings were significant while accounting for the effects of age, cognition at screening, education, and APOE4 carrier status. These findings suggest that women with A+ have early neural resistance to Alzheimer's disease-related amyloid burden. |
| Starting Page | 79 |
| Ending Page | 89 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://content.iospress.com/download/journal-of-alzheimers-disease/jad180028?id=journal-of-alzheimers-disease/jad180028 |
| PubMed reference number | 29865063v1 |
| Alternate Webpage(s) | https://doi.org/10.3233/JAD-180028 |
| DOI | 10.3233/jad-180028 |
| Journal | Journal of Alzheimer's disease : JAD |
| Volume Number | 64 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alzheimer's Disease Amyloid beta-Peptides Apolipoprotein E4 Cognition Disorders Identifier Neuroimaging Positron-Emission Tomography Positrons |
| Content Type | Text |
| Resource Type | Article |
