Caracterización transcriptómica del cáncer de endometrio y su importancia en el diseño de nuevas estrategias terapéuticas

Content Provider	Semantic Scholar
Author	Grande, Mónica Parra
Copyright Year	2018
Abstract	in English, 250 words or less): Background: Endometrial cancer is the most frequent gynecological tumor in development countries. Currently there is a lack of therapeutic options in this type of tumors, which gives rise to a great interest in the search for therapeutic targets that allows the treatment to be customized for the benefit of the patient. The objective of the project was to find out significant differences in the expression of the genes in patients with MSI-H endometrial cancer against MSI-L and MSS, with the objective of finding possible therapeutics options. Methods: To carry out the study, data were obtained from the RNA-seq analysis of samples from patients with TCGA endometrial cancer. The differential expression analysis was carried out using the limma package. Subsequently an analysis of pathway enrichment and gene co-expression was carried out using the ReactomeFIPlugin application through cytoscape version 3.6.1. Finally, the study was completed with a survival analysis of both groups. Results: Significant differences were found in more than 2000 genes or transcripts. Genes or transcripts related to pathways of the cell cycle were found in the MSI-H group, while genes or transcripts related to pathways of the p53 signaling pathway were found in the group MSI-L and MSS. In regard to the survival analysis, there were no significant differences between the two groups. Conclusions: According to the results found in patients with MSI-H endometrial cancer an alternative to the complementary treatment with chemotherapy or radiotherapy could be the CDKs inhibitors.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://openaccess.uoc.edu/webapps/o2/bitstream/10609/82726/6/mparragrandeTFM0618memoria.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article