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MicroRNA-409-3p functions as a tumor suppressor in human lung adenocarcinoma by targeting c-Met.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wan, Li Li Zhu, Lingjun Xu, Jianghao Lu, Binbin Yang, Yucai Liu, Fengzhen Wang, Zhongyan |
| Copyright Year | 2014 |
| Abstract | BACKGROUND/AIMS Dysregulation of microRNAs is correlated with tumor development. The aim of this study is to investigate the clinicopathologic and prognostic significance of microRNA (miR)-409-3p and its tumor suppressor roles in lung adenocarcinoma (LAD). METHODS Quantitative real-time PCR (qRT-PCR) was performed to detect miR-409-3p expression in LAD tissues and corresponding noncancerous tissues. Additionally, the correlations of miR-409-3p expression with clinicopathologic factors and prognosis of patients were statistically analyzed. Next, we investigated whether miR-409-3p could function as a tumor suppressor in LAD cells via regulation of Akt signaling by targeting receptor tyrosine kinase (c-Met). RESULTS MiR-409-3p was significantly downregulated in LAD tissues compared with corresponding noncancerous tissues. Low miR-409-3p expression was observed to be significantly correlated with poorer tumor differentiation, advanced pTNM stage and higher incidence of lymph node metastasis. Multivariate Cox regression analyses showed that miR-409-3p expression was an independent prognostic factor for LAD patients. Functional analyses indicated that miR-409-3p could inhibit growth, induce apoptosis, reduce migration and invasion in LAD cells via inactivation of Akt signaling by targeting c-Met. CONCLUSIONS MiR-409-3p was an independent prognostic factor and functioned as a tumor suppressor in LAD via regulation of Akt signaling by targeting c-Met. |
| Starting Page | 4595 |
| Ending Page | 4604 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.karger.com/Article/Pdf/366337 |
| Alternate Webpage(s) | http://www.karger.com/Article/Pdf/366337 |
| PubMed reference number | 25278243v1 |
| Alternate Webpage(s) | https://doi.org/10.1159/000366337 |
| DOI | 10.1159/000366337 |
| Journal | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology |
| Volume Number | 34 |
| Issue Number | 4 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adenocarcinoma of lung (disorder) Anatomic Node Apoptosis Body tissue Chromosome 3 Short Arm EBV-BART10-3p microRNA Forecast of outcome MET protein, human MicroRNAs Neoplasms Patients Prognostic Factors Protein Tyrosine Kinase Proto-Oncogene Proteins c-akt Receptor Protein-Tyrosine Kinases Regression Analysis Reverse Transcriptase Polymerase Chain Reaction Tumor Suppressor Genes cellular targeting lymph node metastases |
| Content Type | Text |
| Resource Type | Article |
