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Author's report Title : Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors Version : 1 Date : 7 December 2011
| Content Provider | Semantic Scholar |
|---|---|
| Author | Allavena, Paola |
| Abstract | The authors highlight the correlation between EMT gene and protein expression and the presence of macrophage clusters in tumors. To demonstrate that macrophages produce molecules able to induce EMT, they treated two tumor cell lines with the conditioned medium of a macrophage cell line (activated with Th2 cytokines). They observe that epithelial markers decrease and mesenchymal markers increase when cells are treated with conditioned medium, with a TGFbeta-dependent mechanism. Furthermore they demonstrate that in patient samples of NSCLC there is a positive correlation between intratumoral macrophages densities and EMT markers. They conclude that tumor-associated macrophages modulate EMT by producing TGFbeta. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://static-content.springer.com/openpeerreview/art:10.1186%2F1471-2407-12-35/12885_2011_3085_ReviewerReport_V1_R2.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
