NDLI: Management consensus guidance for the use of rivaroxaban--an oral, direct factor Xa inhibitor.

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Management consensus guidance for the use of rivaroxaban--an oral, direct factor Xa inhibitor.

Content Provider	Semantic Scholar
Author	Turpie, Alexander G. G. Kreutz, Reinhold Llau, Juan Vicente Norrving, Bo Haas, Sylvia
Copyright Year	2012
Abstract	A number of novel oral anticoagulants that directly target factor Xa or thrombin have been developed in recent years. Rivaroxaban and apixaban (direct factor Xa inhibitors) and dabigatran etexilate (a direct thrombin inhibitor) have shown considerable promise in large-scale, randomised clinical studies for the management of thromboembolic disorders, and have been approved for clinical use in specific indications. Rivaroxaban is licensed for the prevention of venous thromboembolism in patients undergoing elective hip or knee replacement surgery, the treatment of deep-vein thrombosis and prevention of recurrent venous thromboembolism, and for stroke prevention in patients with non-valvular atrial fibrillation. Based on the clinical trial data for rivaroxaban, feedback on its use in clinical practice and the authors' experience with the use of rivaroxaban, practical guidance for the use of rivaroxaban in special patient populations and specific clinical situations is provided. Although most recommendations are in line with the European summary of product characteristics for the approved indications, additional and, in several areas, different recommendations are given based on review of the literature and the authors' clinical experience.
File Format	PDF HTM / HTML
DOI	10.1160/TH12-03-0209
PubMed reference number	23014816
Journal	Medline
Volume Number	108
Issue Number	5
Alternate Webpage(s)	https://th.schattauer.de/en/contents/archive/issue/1599/manuscript/18242/download.html
Alternate Webpage(s)	http://www.precisdanesthesiecardiaque.ch/Pdf/AnnEAnesth/Rivaroxaban.pdf
Alternate Webpage(s)	https://doi.org/10.1160/TH12-03-0209
Journal	Thrombosis and haemostasis
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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