Loading...
Please wait, while we are loading the content...
Similar Documents
Heterologous expression of metabotropic glutamate receptors in adult rat sympathetic neurons: Subtype-specific coupling to ion channels
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ikeda, Stephen R. Lovinger, David M. McCool, Brian A. Lewis, Deborah L. |
| Copyright Year | 1995 |
| Abstract | A novel heterologous expression system was used to examine the coupling of metabotropic glutamate receptors (mGluRs) to neuronal voltage-gated ion channels. Cytoplasmic injection of mGluR2 cRNA into adult rat sympathetic neurons resulted in the expression of receptors that negatively coupled to N-type Ca2+ channels through a pertussis toxin-sensitive pathway. Injection of mGluR1 alpha cRNA resulted in the expression of receptors that inhibited M-type K+ channels via a pertussis toxin-insensitive pathway. Coupling was restricted to specific transduction elements and effectors, since mGluR2 did not inhibit M channels and mGluR1 alpha had minimal effects on Ca2+ channels. These findings demonstrate that heterologously expressed, and thus unambiguously identified, mGluR subtypes modulate specific neuronal ion channels through discrete signal transduction pathways. |
| Starting Page | 1029 |
| Ending Page | 1038 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0896-6273(95)90341-0 |
| PubMed reference number | 7538309 |
| Journal | Medline |
| Volume Number | 14 |
| Alternate Webpage(s) | https://core.ac.uk/download/pdf/81987315.pdf |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0896627395903410 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0896627395903410 |
| Alternate Webpage(s) | https://doi.org/10.1016/0896-6273%2895%2990341-0 |
| Journal | Neuron |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
