NDLI: Long term neurotoxicity of styrene. A quantitative study of glial fibrillary acidic protein (GFA) and S-100.

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Long term neurotoxicity of styrene. A quantitative study of glial fibrillary acidic protein (GFA) and S-100.

Content Provider	Semantic Scholar
Author	Rosengren, Lars E. Haglid, Kenneth G.
Copyright Year	1989
Abstract	Little information exists about the possible neurotoxicity of styrene. The present study was designed to explore whether long term inhalation exposure (three months) to styrene (90 and 320 ppm) could induce long lasting astroglial alterations in Sprague Dawley rats, traceable four months after exposure ceased. Styrene exposure at 320 ppm induced such alterations as shown by raised concentrations of the glial cell marker, glial fibrillary acidic protein (GFA) in the sensory motor cortex and in the hippocampus. GFA is the structural protein of the astroglial filaments and formation of these filaments has been shown after damage to the central nervous system from any cause. It is concluded that exposure to styrene at moderate exposure levels induces regional, long lasting astroglial reactions that serve as an indicator of solvent induced brain damage.
File Format	PDF HTM / HTML
DOI	10.1136/oem.46.5.316
PubMed reference number	2751929
Journal	Medline
Volume Number	46
Issue Number	5
Alternate Webpage(s)	http://oem.bmj.com/content/oemed/46/5/316.full.pdf
Alternate Webpage(s)	http://europepmc.org/articles/pmc1009774?pdf=render
Journal	British journal of industrial medicine
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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