Cross-sectional associations between dietary intake and carotid intima media thickness in type 2 diabetes: baseline data from a randomised trial

Content Provider	Semantic Scholar
Author	Chiavaroli, Laura Mirrahimi, Arash Ireland, Christopher Mitchell, Sandra Sahye-Pudaruth, Sandhya Coveney, Judy Olowoyeye, Omodele Patel, Darshna Souza, Russell J. De Augustin, Livia S. A. Bashyam, Balachandran Pichika, Sathish Chandra Mejia, Sonia Blanco Nishi, Stephanie K. Leiter, Lawrence A. Josse, Robert G. Mckeown-Eyssen, Gail E. Moody, Alan R. Kendall, Cyril W. C. Sievenpiper, John L. Jenkins, David J. A.
Copyright Year	2017
Abstract	OBJECTIVE To assess associations between dietary intake and carotid intima media thickness (CIMT) by carotid ultrasound (CUS), a surrogate marker of cardiovascular disease (CVD) risk, in those with type 2 diabetes. DESIGN Cross-sectional analysis of baseline data from 325 participants from three randomised controlled trials collected in the same way. SETTING Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Canada. PARTICIPANTS 325 participants with type 2 diabetes, taking oral antidiabetic agents, with an HbA1c between 6.5% and 8.0% at screening, without a recent cardiovascular event. MAIN OUTCOME MEASURES CIMT by CUS and associations with dietary intake from 7-day food records, as well as anthropometric measures and fasting serum samples. RESULTS CIMT was significantly inversely associated with dietary pulse intake (β=-0.019, p=0.009), available carbohydrate (β=-0.004, p=0.008), glycaemic load (β=-0.001, p=0.007) and starch (β=-0.126, p=0.010), and directly associated with total (β=0.004, p=0.028) and saturated (β=0.012, p=0.006) fat intake in multivariate regression models adjusted for age, smoking, previous CVD event, blood pressure medication, antidiabetic medication and ultrasonographer. CONCLUSIONS Lower CIMT was significantly associated with greater consumption of dietary pulses and carbohydrates and lower total and saturated fat intake, suggesting a potential role for diet in CVD risk management in type 2 diabetes. Randomised controlled trials are anticipated to explore these associations further. TRIAL REGISTRATION NUMBER NCT01063374.
File Format	PDF HTM / HTML
DOI	10.1136/bmjopen-2016-015026
PubMed reference number	28336747
Journal	Medline
Volume Number	7
Alternate Webpage(s)	http://bmjopen.bmj.com/content/bmjopen/7/3/e015026.full.pdf
Alternate Webpage(s)	https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4d/75/bmjopen-2016-015026.PMC5372138.pdf
Alternate Webpage(s)	https://doi.org/10.1136/bmjopen-2016-015026
Journal	BMJ open
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article