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Correlation of CCL20 expression in rectal mucosa with the development of ulcerative colitis-associated neoplasia
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hashimoto, Kiyoshi Saigusa, Susumu Araki, Toshimitsu Tanaka, Koji Okita, Yoshiki Fujikawa, Hiroyuki Kawamura, Mikio Okugawa, Yoshinaga Toiyama, Yuji Inoue, Yasuhiro Uchida, Keiichi Mohri, Yasuhiko Kusunoki, Masato |
| Copyright Year | 2013 |
| Abstract | Chronic inflammation increases the risk of developing several gastrointestinal malignancies. Chemokines that are produced by colonic epithelial cells play significant roles in the maintenance and repair of the epithelial barrier. The present study aimed to clarify whether the expression of CCL20 and its receptor, CCR6, was correlated with the development of ulcerative colitis (UC)-associated neoplasia. A total of 93 patients with UC who underwent proctocolectomies were enrolled in the present study. Immunohistochemical analysis for CCL20 and CCR6 expression in the rectal mucosa was performed and the correlation between expression and the pathogenesis of UC-associated neoplasia was investigated. A total of 16 (17.2%) patients presented with UC-associated neoplasia. The immunohistochemistry (IHC) score for CCL20 was significantly increased in the patients with a mild form of the disease (P=0.0363). The IHC score for CCL20 expression in the patients with UC-associated neoplasia was higher compared with the patients without neoplasia (P=0.0294). In contrast, there was no significant correlation between CCR6 expression and the clinicopathological variables. The logistic regression analysis revealed that a high IHC score for CCL20 expression in the rectal mucosa and a disease duration of more than eight years were significantly correlated with the development of UC-associated neoplasia (P<0.05). The results suggest that an evaluation of CCL20 expression in the rectal mucosa may be useful to identify patients who are at a high risk for developing UC-associated neoplasia. However, a selection bias existed in the present study due to the fact that the patient population that was enrolled was not representative of a typical surveillance patient population. |
| Starting Page | 1271 |
| Ending Page | 1276 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.spandidos-publications.com/10.3892/ol.2013.1528/download |
| Alternate Webpage(s) | http://ftp.ncbi.nlm.nih.gov/pub/pmc/4b/db/ol-06-05-1271.PMC3813524.pdf |
| PubMed reference number | 24179507 |
| Volume Number | 6 |
| Journal | Oncology letters |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | CCL20 gene CCR6 protein, human Gastrointestinal Diseases Immunohistochemistry Multiple Endocrine Neoplasia Type 2a Neoplasms Patients Rectal Dosage Form TUBE,RECTAL,24FR,PLASTIC B#6510 Thymic T-Cell Selection Ulcer Ulcerative Colitis |
| Content Type | Text |
| Resource Type | Article |
