NDLI: SRD5A2 gene polymorphisms and the risk of benign prostatic hyperplasia but not prostate cancer.

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SRD5A2 gene polymorphisms and the risk of benign prostatic hyperplasia but not prostate cancer.

Content Provider	Semantic Scholar
Author	Choubey, Vimal Kumar Sankhwar, Satya Narayan Carlus, Silas Justin Singh, Anand Narayan Dalela, Diwakar Thangaraj, K. Rajender, Singh
Copyright Year	2015
Abstract	BACKGROUND Testosterone, a primary androgen in males, is converted into its most active form, dihydrotestosterone (DHT), by 5α-reductase type 2 (encoded by the SRD5A2 gene) in the prostate. DHT is necessary for prostatic growth and has five times higher binding affinity than testosterone for androgen receptors. We hypothesized that polymorphic variations in the SRD5A2 gene may affect the risk of benign prostatic hyperplasia and prostate cancer. MATERIALS AND METHODS We analyzed SRD5A2 gene polymorphisms in 217 BPH patients, 192 PCa cases, and 171 controls. Genotyping was undertaken using direct DNA sequencing. Genotype data were compared between cases and controls using a Chi square statistical tool. RESULTS We found that the A49T locus was monomorphic with 'AA' genotype in all subjects. At V89L locus, the presence of 'VV' showed a marginally significant correlation with increased BPH risk (p=0.047). At the (TA)n locus, longer TA repeats were found to be protective against BPH (p=0.003). However, neither of these polymoprhisms correlated with the risk of PCa. CONCLUSIONS We conclude that A49T is monomorphic in the study population, VV marginally correlates with BPH risk, and longer (TA)n repeats are protective against BPH. None of these polymorphisms affect the risk of PCa.
Starting Page	1657
Ending Page	1660
Page Count	4
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://ocean.kisti.re.kr/downfile/volume/apocp/POCPA9/2015/v16n3/POCPA9_2015_v16n3_1033.pdf
Alternate Webpage(s)	http://www.apocpcontrol.org/paper_file/issue_abs/Volume16_No3/1033-1036%209.27%20Vimal%20Kumar%20Choubey.pdf
PubMed reference number	25735326v1
Volume Number	16
Issue Number	3
Journal	Asian Pacific journal of cancer prevention : APJCP
Language	English
Access Restriction	Open
Subject Keyword	Amino Acids Androgen Receptor Androgens Benign Prostatic Hyperplasia Dihydrotestosterone Genetic Polymorphism Patients Prostate Prostatic Neoplasms Tai Ji Testosterone
Content Type	Text
Resource Type	Article

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