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[Simultaneous determination of clopidol, sulfonamide and quinolone residues in chickens by ultra performance liquid chromatography-tandem mass spectrometry].
| Content Provider | Semantic Scholar |
|---|---|
| Author | Song, Wei Hu, Yanyun Han, Fang Lü, Yaning Zheng, Ping Zhou, Fangfang Chen, Xiaomei Qiu, Jing Zhou, Xiaoying |
| Copyright Year | 2013 |
| Abstract | An analytical method for the simultaneous determination of clopidol, sulfadiazine, sulfamethazine, sulfametoxydiazine, sulfamethoxypyridazine, norfloxacin, ofloxacin, ciprofloxacin, enrofloxacin in chickens by ultra performance liquid chromatography coupled with tandem quadrupole mass spectrometry (UPLC-MS/MS) in positive ion mode with multiple reaction monitoring (MRM) has been developed and validated. The samples were homogenized and extracted with acetonitrile. After defatted with high speed frozen centrifugation, the supernatant solution was evaporated and the residue was dissolved with the mobile phase and defatted with n-hexane. It was then analyzed with UPLC-MS/MS. The limit of detection of this method was 0.1 microg/kg, and the limit of quantification was 0.5 microg/kg. The average recoveries (spiked at the levels of 0.5, 1.0, 2.0 microg/kg) ranged from 81.5% to 97.6%, with the relative standard deviations between 2.1% and 8.9%. The results demonstrated that the method is simple, accurate and suitable for the identification and quantification of these drug residues in chickens. |
| File Format | PDF HTM / HTML |
| DOI | 10.3724/sp.j.1123.2013.08022 |
| PubMed reference number | 24669706 |
| Journal | Medline |
| Volume Number | 31 |
| Issue Number | 12 |
| Journal | Se pu = Chinese journal of chromatography |
| Alternate Webpage(s) | http://www.chrom-china.com/fileup/PDF/sp1308022.pdf |
| Alternate Webpage(s) | https://doi.org/10.3724/sp.j.1123.2013.08022 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
