NDLI: Nontoxic, nonvolatile, and highly efficient osmium catalysts for asymmetric dihydroxylation of alkenes and application to one mol-scale synthesis of an anticancer drug, camptothecin intermediate

Content Provider	Semantic Scholar
Author	Akiyama, Ryo Matsuki, Norio Nomura, Hiroshi Yoshida, Hisao Yoshida, Tomoko Kobayashi, Shū
Copyright Year	2012
Abstract	Novel polymer-incarcerated osmium (PI Os) catalysts have been developed. The Os catalysts were shown to be nontoxic and nonvolatile, and stable for several months in air. Asymmetric dihydroxylation of alkenes using these Os catalysts proceeded smoothly to afford the corresponding diols in high yields with high enantioselectivities. The catalysts could be recovered and reused. One mol-scale preparation of a key intermediate for camptothecin, an anticancer drug, has also been successfully demonstrated by using the catalysts.
Starting Page	7456
Ending Page	7461
Page Count	6
File Format	PDF HTM / HTML
DOI	10.1039/C2RA21123H
Volume Number	2
Alternate Webpage(s)	http://www.rsc.org/suppdata/ra/c2/c2ra21123h/c2ra21123h.pdf
Alternate Webpage(s)	https://doi.org/10.1039/C2RA21123H
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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