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A randomized trial of temperature-controlled radiofrequency, continuous positive airway pressure, and placebo for obstructive sleep apnea syndrome.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Woodson, B. Tucker Steward, David L. Weaver, Edward M. Javaheri, Shahrokh |
| Copyright Year | 2003 |
| Abstract | OBJECTIVE The study goal was to determine the effectiveness of (1) multilevel temperature-controlled radiofrequency tissue ablation (TCRFTA) or (2) continuous positive airway pressure (CPAP) for the treatment of mild to moderate obstructive sleep apnea syndrome (OSAS). STUDY DESIGN AND METHODS We conducted a randomized, placebo-controlled, 2-site trial, comparing TCRFTA (n = 30) and CPAP (n = 30) with sham-placebo (n = 30) using intention-to-treat analysis. RESULTS Compared with pretreatment baseline, TCRFTA improved reaction time, OSAS-specific quality of life (QOL), and subjective sleepiness (all P < 0.05). Compared with sham-placebo, TCRFTA improved QOL, airway volume, apnea index, and respiratory arousal index (all P < 0.05). TCRFTA side effects and complications were mild, temporary, and similar to sham-placebo. CPAP improved QOL and sleepiness compared with baseline and QOL when compared with sham-placebo (all P < 0.05). Significant differences were not seen between TCRFTA and CPAP outcomes. CONCLUSION TCRFTA and CPAP each improve QOL for mild-moderate OSAS patients. TCRFTA improvements may result from changes in airway volume, apnea index, and respiratory arousal index. |
| Starting Page | 1 |
| Ending Page | 9 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://depts.washington.edu/ccor/studies/SleepApnea/files/RF%20Tongue-Palate%20RCT%20(Oto-HNS%202003).pdf |
| PubMed reference number | 12825037v1 |
| Volume Number | 128 |
| Issue Number | 6 |
| Journal | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Arousal Continuous Positive Airway Pressure Morbidity - disease rate Patients Perceived quality of life Sleep Apnea Syndromes Sleep Apnea, Obstructive Somnolence TORG-WINCHESTER SYNDROME Therapeutic procedure Zygote Intrafallopian Transfer radiofrequency |
| Content Type | Text |
| Resource Type | Article |
