NDLI: Neurogenic Inflammation of Guinea-Pig Bladder

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Neurogenic Inflammation of Guinea-Pig Bladder

Content Provider	Semantic Scholar
Author	Bjorling, Dale E. Saban, Marcia R. Saban, Ricardo
Copyright Year	1994
Abstract	Capsaicin, substance P, and ovalbumin, instilled into the bladders of naive and ovalbumin (OVA) sensitized guineapigs caused inflammation, as indicated by increased vascular permeability. Histological changes after exposure to these compounds progressed with time from intense vasodilatation to marginalization of granulocytes followed by interstitial migration of leukocytes. In vitro incubation of guinea-pig bladder tissue with substance P and ovalbumin stimulated release of prostaglandin D(2) and leukotrienes. In vitro incubation of bladder tissue with capsaicin, OVA, prostaglandin D(2), leukotriene C(4), histamine, or calcium ionophore A-23587 all stimulated substance P release. These data suggest that bladder inflammation initiated by a variety of stimuli could lead to a cyclic pattern of release of inflammatory mediators and neuropeptides, which could result in amplification and persistence of cystitis after the inciting cause has subsided.
Starting Page	189
Ending Page	197
Page Count	9
File Format	PDF HTM / HTML
PubMed reference number	18472941
Volume Number	3
Journal	Mediators of inflammation
Alternate Webpage(s)	https://pdfs.semanticscholar.org/5e9b/ad02fc6209829c28e8be08c1c9dfb5bf8c62.pdf
Language	English
Access Restriction	Open
Subject Keyword	Bladder Neoplasm Bladder Tissue Calcium Capsaicin Cystitis Histamine Ionophores Leukotriene Antagonists Leukotrienes Neurogenic Inflammation Ovalbumin Prostaglandin Antagonists Prostaglandin-Endoperoxide Synthase Prostaglandins Substance P Urinary Bladder Vasodilation granulocyte
Content Type	Text
Resource Type	Article

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