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Title : Comparative efficacy and safety of intravenous ferric carboxymaltose in treatment of post-partum iron deficiency anemia . Subtitle : Parenteral iron carboxymaltose for post-partum anemia
| Content Provider | Semantic Scholar |
|---|---|
| Author | Breymann, Christian Gliga, Fotinica Bejenariu, Constantin Strizhova, N. V. |
| Copyright Year | 2008 |
| Abstract | OBJECTIVES: To compare the safety and efficacy of iron carboxymaltose with ferrous sulfate to treat iron deficiency anemia in the post partum. METHODS: Patients were randomized (2:1 ratio) to receive iron carboxymaltose (up to 3 weekly doses of 1000 mg maximum, applied in 15 min; n=227) or ferrous sulfate (100 mg twice daily, 12 weeks; n=117). Changes in hemoglobin and iron stores up to week 12 were analyzed. RESULTS: Iron carboxymaltose was as effective as oral iron sulfate in changing hemoglobin, despite the much shorter treatment period (2 weeks vs 12 weeks). Ferritin levels were significantly higher. Except for injection site burning, iron carboxymaltose was better tolerated than ferrous sulfate, mainly concerning gastrointestinal side effects. There were no safety concerns identified in breast-fed infants. CONCLUSION: Parenteral iron carboxymaltose is a safe and effective treatment option for postpartum anemia, with advantages of a shorter treatment period, better compliance, rapid normalization of iron storages, and lower incidence of gastrointestinal side effects. Breymann et al. 2007 1 International Journal of Gynecology and Obstetrics Final October 08, 2007 Title: Comparative efficacy and safety of intravenous ferric carboxymaltose in treatment of post-partum iron deficiency anemia. Subtitle: Parenteral iron carboxymaltose for post-partum anemia Authors: C. Breymann, F.N. Gliga, C.N. Bejenariu, N. Strizhova. § Corresponding author. a Obstetric Research, Feto-maternal Hematology Unit, University Hospital Zurich, Switzerland. b Spitalul de Obstetrica-Ginecologie “Dr. Ioan Aurel Sbarcea”, Brasov, Romania. c Institutul pentru Ocrotirea Mamei si Copilului, Departamentul de Obstetrica-Ginecologie Polizu, Bucharest, Romania. d Maternity Hospital No. 3, Moscow, Russia. Correspondence to: Christian Breymann, MD, Lecturer; Department of Obstetrics and Gynaecology, Clinic of Obstetrics, Obstetric Research,University Hospital Zurich, Frauenklinikstr. 10, CH-8091 Zurich, Switzerland. Phone: +41 1 255 1111/5134 Fax: +41 1 255 4430 Email: christian.breymann@usz.ch |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.zora.uzh.ch/id/eprint/8123/2/Breymann_8123_V.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
