Microvascular tone in a skeletal muscle of spontaneously hypertensive rats.

Content Provider	Semantic Scholar
Author	Schmid-Schönbein, Geert W. Zweifach, Benjamin W. DeLano, Frank A. Chen, Peter C. Y.
Copyright Year	1987
Abstract	We studied the degree of arteriolar smooth muscle constriction in the spinotrapezius muscle microcirculation of spontaneously hypertensive rats and their normotensive controls, Wistar-Kyoto rats. The constriction was expressed in the form of a nondimensional tone as the difference between steady state and dilated diameter (after papaverine treatment) divided by the dilated diameter. Both animal strains showed on average a progressive increase of tone toward the more distal arterioles, with a peak tone being reached in the transverse arterioles. Tone values in the hypertensive animals were consistently elevated. The number of arterioles that had more than 5% tone (so-called responder arterioles) was higher in the hypertensive animals. These studies suggest that, besides the anatomical adjustments documented earlier in our laboratory in the arteriolar network of this muscle, functional adjustments in the form of an elevated microvascular tone are associated with the elevated resistance in spontaneously hypertensive rats.
Starting Page	691
Ending Page	700
Page Count	10
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://hyper.ahajournals.org/content/hypertensionaha/9/2/164.full.pdf?download=true
Alternate Webpage(s)	http://hyper.ahajournals.org/content/9/2/164.full.pdf
PubMed reference number	3818013v1
Volume Number	9
Issue Number	2
Journal	Hypertension
Language	English
Access Restriction	Open
Subject Keyword	Animal Organism Strain Diameter (qualifier value) Document completion status - Documented Hypertensive disease Microcirculation Papaverine Rats, Inbred SHR Skeletal muscle structure Smooth muscle (tissue) Structure of arteriole
Content Type	Text
Resource Type	Article