Loading...
Please wait, while we are loading the content...
Similar Documents
Effect of hypoxia on arterial baroreflex control of heart rate and muscle sympathetic nerve activity in humans.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Halliwill, John R. Minson, Christopher T. |
| Copyright Year | 2002 |
| Abstract | We tested the hypothesis that acute hypoxia would alter the sensitivity of arterial baroreflex control of both heart rate and sympathetic vasoconstrictor outflow. In 16 healthy, nonsmoking, normotensive subjects (8 women, 8 men, age 20-33 yr), we assessed baroreflex control of heart rate and muscle sympathetic nerve activity by using the modified Oxford technique during both normoxia and hypoxia (12% O(2)). Compared with normoxia, hypoxia reduced arterial O(2) saturation levels from 96.8 +/- 0.3 to 80.7 +/- 1.4% (P < 0.001), increased heart rate from 59.8 +/- 2.4 to 79.4 +/- 2.9 beats/min (P < 0.001), increased mean arterial pressure from 96.7 +/- 2.5 to 105.0 +/- 3.3 mmHg (P = 0.002), and increased sympathetic activity 126 +/- 58% (P < 0.05). The sensitivity for baroreflex control of both heart rate and sympathetic activity was not altered by hypoxia (heart rate: -1.02 +/- 0.09 vs. -1.02 +/- 0.11 beats. min(-1). mmHg(-1); nerve activity: -5.6 +/- 0.9 vs. -6.2 +/- 0.9 integrated activity. beat(-1). mmHg(-1); both P > 0.05). Acute exposure to hypoxia reset baroreflex control of both heart rate and sympathetic activity to higher pressures without changes in baroreflex sensitivity. |
| File Format | PDF HTM / HTML |
| DOI | 10.1152/japplphysiol.01103.2001 |
| PubMed reference number | 12183478 |
| Journal | Medline |
| Volume Number | 93 |
| Issue Number | 3 |
| Alternate Webpage(s) | http://jap.physiology.org/content/jap/93/3/857.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.1152/japplphysiol.01103.2001 |
| Journal | Journal of applied physiology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
