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Trends in Malignancies among Korean Patients Infected with Human Immunodeficiency Virus in the Highly Active Antiretroviral Therapy Era
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lee, Shinwon Lee, Sun Hee Lee, Jeong Eun Kang, Jin Suk Lee, Seung Geun Chung, Joo Seop Kwak, Ihm Soo |
| Copyright Year | 2017 |
| Abstract | Since the introduction of highly active antiretroviral therapy, the life span of people with human immunodeficiency virus (HIV) or AIDS (PWHA) has been extended significantly. Therefore, the importance of non-AIDS-defining cancers (NADCs), as well as AIDS-defining cancers (ADCs) has increased. There is little information concerning the epidemiology of malignancies in PWHA in Korea. A descriptive epidemiologic study was conducted at a tertiary care hospital in Korea. PWHA who visited Pusan National University Hospital from January 2000 to October 2014 were included. Demographics and clinical data were obtained from the medical records and analyzed. A total of 950 PWHA were observed for 4,439.71 person-years. Forty-eight episodes (5.05%) of cancers were diagnosed in 47 patients. Mean age of the enrolled patients was 40.66 ± 12.15 years and 88% were male. Among the 48 cancer episodes, 20 (42%) were ADCs and 28 were NADCs. The most common ADCs was non-Hodgkin's lymphoma (53.6%), followed by Kaposi's sarcoma (17.9%). The most common NADCs were lung cancer (25%) and hepatocellular carcinoma (25%). The overall incidence of total cancers, ADCs, and NADCs was 10.8 (95% confidence interval [CI], 8.0-14.3), 4.5 (95% CI, 2.8-7.0), and 6.3 (95% CI, 4.2-9.1)/1,000 person-years, respectively. NADCs accounted for 12/15 (80%) of cancers among PWHA with good adherence to care. The 5-year survival rate of PWHA and NADC was 26.3%. NADCs have become the main type of malignancy among Korean PWHA with good adherence to care. Effective strategies to improve screening of NADCs among PWHA are required in Korea. |
| Starting Page | 1445 |
| Ending Page | 1450 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 28776339v1 |
| Alternate Webpage(s) | https://doi.org/10.3346/jkms.2017.32.9.1445 |
| DOI | 10.3346/jkms.2017.32.9.1445 |
| Journal | Journal of Korean medical science |
| Volume Number | 32 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | AIDS-related malignancies Accident and Emergency department Acquired Immunodeficiency Syndrome Antiretroviral Therapy, Highly Active Antiretroviral therapy Carcinoma of lung Confidence Intervals Demography Description Epidemiology HIV Infections Immunologic Deficiency Syndromes Kaposi Sarcoma Liver carcinoma Lymphoma Lymphoma, Non-Hodgkin Malignant Neoplasms N-acetoacetyl-N-deacetylcolchicine Patients Tertiary Healthcare non-T, non-B childhood acute lymphoblastic leukemia |
| Content Type | Text |
| Resource Type | Article |
