Ventricular arrhythmias and electrophysiological consequences of myocardial ischemia and infarction.

Content Provider	Semantic Scholar
Author	Lazzara, Ralph El-Sherif, Nabil Hope, Ronald R. Scherlag, Benjamin J.
Copyright Year	1978
Abstract	The derangements of cardiac rhythm that result from occlusion of coronary arteries caught the attention of the earliest experimenters in the field. By the time of the studies of Porter in 1894, it was known that "fibrillar contractions" often were the end result of coronary occlusion and that irregularities of cardiac rhythm commonly preceded terminal ventricular fibrillation. Porter remarked that the pioneer investigator, Erichsen, in 1842, saw a "slight tremulous motion" after cessation of the regular heart beat following coronary occlusion. To Porter, disturbance of the cardiac rhythm was the salient feature of coronary occlusion. Thomas Lewis, in 1909, demonstrated the relationship of paroxysmal ventricular tachycardia to coronary occlusion in experimental animals; Robinson and Hermann, in 1921, established this relationship in man. Clinicians observed a multitude of arrhythmias resulting from ischemia and infarction but the fascination of experimenters with ischemic rhythm disorders waned. During the first half of the 20th century, the attention of researchers was focused more on the effects of ischemia and infarction on the configuration of the ventricular complexes, the QRS and T waves, than on rhythm.
File Format	PDF HTM / HTML
DOI	10.1161/01.RES.42.6.740
Alternate Webpage(s)	http://circres.ahajournals.org/content/circresaha/42/6/740.full.pdf?origin=publication_detail
PubMed reference number	350449
Alternate Webpage(s)	https://doi.org/10.1161/01.RES.42.6.740
Journal	Medline
Volume Number	42
Issue Number	6
Journal	Circulation research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article