NDLI: Lack of association between IL1A c.-889 C>T gene polymorphism and chronic periodontitis in subjects from Bahia, Brazil

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Lack of association between IL1A c.-889 C>T gene polymorphism and chronic periodontitis in subjects from Bahia, Brazil

Content Provider	Semantic Scholar
Author	Oliveira, Kamilla Menezes Alcântara, Lucas Magalhães Teixeira, Fernanda Gabriela Mendonça, Samir Andrade Santos, Djanilson Barbosa Dos Marques, Lucas Miranda Amorim, Maise Mendonça Gestinari, Raquel De Souza
Copyright Year	2015
Abstract	Aim: This study aimed to analyze the relationship between the polymorphism c.-889 C>T in the IL1A gene and periodontitis in subjects from Vitoria da Conquista, Bahia, Brazil. Methods: Two hundred fifty-nine individuals were classified according to periodontitis diagnoses in cases and controls. Genomic DNA was extracted from buccal epithelial cells. Genotyping was performed by PCR-RFLP, followed by agarose gel electrophoresis. Data were analyzed using Chi-square, Fisher’s exact and Hosmer-Lemeshow tests. Results: In the individuals evaluated in this study, periodontitis was significantly associated with a low educational level (p = 0.024) and clinical variables, such as gingival bleeding (p = 0.019) and tooth mobility (p = 0.001). Among patients in the case group, the majority (72.88%) had a generalized form of periodontitis. The genotypic frequencies for IL1A c.–889 C>T between the case and control groups did not significantly differ (χ2 = 1.6983; p = 0.428). Conclusion: This study’s findings indicate the lack of association between periodontitis and the IL1A c -889 C>T gene polymorphism. Uniterms: Peridontitis. Genetic polymorphism. Interleukin-1.
Starting Page	170
Ending Page	178
Page Count	9
File Format	PDF HTM / HTML
Volume Number	51
Alternate Webpage(s)	https://seer.ufmg.br/index.php/arquivosemodontologia/article/download/2197/1597
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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