NDLI: Dextran Gadolinium Complexes as Contrast Agents for Magnetic Resonance Imaging to Sentinel Lymph Nodes

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Dextran Gadolinium Complexes as Contrast Agents for Magnetic Resonance Imaging to Sentinel Lymph Nodes

Content Provider	Semantic Scholar
Author	Yan, Guo-Ping Yang, Lian Li, Liang Guo, Qing-Zhong
Copyright Year	2010
Abstract	ABSTRACTPurposeThe aim was to investigate three dextran gadolinium complexes Dextran-DTPA-Gd as the potential MRI contrast agents in lymphatic system.MethodsThree dextran gadolinium complexes Dextran-DTPA-Gd containing differing amounts of Gd-DTPA were synthesized by the incorporation of Gd-DTPA to the hydroxyl groups of dextran. These dextran ligands and gadolinium complexes were characterized, and their properties in vitro and in vivo were also evaluated.ResultsDextran-DTPA-Gd demonstrated obviously higher relaxation effectiveness than that of Gd-DTPA. The result of in vitro cytotoxicity assay showed that these macromolecular ligands and their corresponding gadolinium complexes had low cytotoxicity to HeLa cells. Dextran-DTPA-Gd greatly enhanced the contrast of MR images of normal politeal lymph nodes and reactive hyperplasia of politeal lymph nodes in rabbits and provided prolonged duration in lymphatic system with lower injection doses than that of Gd-DTPA. However, Dextran-DTPA-Gd displayed low signal enhancements in MR images of politeal lymph nodes with VX2 carcinoma in rabbits during the detection time.ConclusionsThese dextran gadolinium complexes Dextran-DTPA-Gd can be taken up selectively by lymphatic system and showed the potential as MRI contrast agents in lymphatic system.
Starting Page	1884
Ending Page	1892
Page Count	9
File Format	PDF HTM / HTML
DOI	10.1007/s11095-010-0187-6
PubMed reference number	20559699
Journal	Medline
Volume Number	27
Alternate Webpage(s)	http://or.nsfc.gov.cn/bitstream/00001903-5/121648/1/1000001227623.pdf
Alternate Webpage(s)	https://doi.org/10.1007/s11095-010-0187-6
Journal	Pharmaceutical Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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