NDLI: Cancer esearch cular and Cellular Pathobiology Mitotic Kinase Aurora-A Induces Mammary l Migration and Breast Cancer Metastasis R ctivating the Cofilin-F-actin Pathway

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Cancer esearch cular and Cellular Pathobiology Mitotic Kinase Aurora-A Induces Mammary l Migration and Breast Cancer Metastasis R ctivating the Cofilin-F-actin Pathway

Content Provider	Semantic Scholar
Author	Wang Xiang, Jin Xin Zhang, Yan Zhao, Yan Yue, Cai-Feng Zheng, Fei-Meng Chen Kang, Zhuang Chen, Tong-Sheng Xing, Da Liu, Quentin
Copyright Year	2010
Abstract	nloaded mitotic kinase Aurora-A (Aur-A) is required to form the bipolar spindle and ensure accurate chromosegregation before cell division. Aur-A dysregulation represents an oncogenic event that promotes tumor tion. Here, we report that Aur-A promotes breast cancer metastasis. Aur-A overexpression enhanced ary cell migration by dephosphorylation and activation of cofilin, which facilitates actin reorganization lymerization. Cofilin knockdown impaired Aur-A–driven cell migration and protrusion of the cell memConversely, overexpression of activated cofilin abrogated the effects of Aur-A knockdown on cell min. Moreover, Aur-A overexpession increased the expression of the cofilin phosphatase Slingshot-1 ), contributing to cofilin activation and cell migration. We found that phosphatidylinositol 3-kinase inhibition blocked Aur-A–induced cofilin dephosphorylation, actin reorganization, and cell migration, ting crosstalk with PI3K signaling and a potential benefit of PI3K inhibition in tumors with deregulated . Additionally, we found an association between Aur-A overexpression and cofilin activity in breast tissues. Our findings indicate that activation of the cofilin-F-actin pathway contributes to tumor cell cancer migration and metastasis enhanced by Aur-A, revealing a novel function for mitotic Aur-A kinase in tumor progression. Cancer Res; 70(22); 9118–28. ©2010 AACR.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://cancerres.aacrjournals.org/content/canres/70/22/9118.full.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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