NDLI: Thiorphan-induced neprilysin inhibition raises amyloid β levels in rabbit cortex and cerebrospinal fluid

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Thiorphan-induced neprilysin inhibition raises amyloid β levels in rabbit cortex and cerebrospinal fluid

Content Provider	Semantic Scholar
Author	Newell, Amanda J. Sue, Lucia I. Scott, Sarah Rauschkolb, Paula K. Beach, Thomas G.
Copyright Year	2003
Abstract	Studies on the pathogenesis of Alzheimer's disease (AD) suggest overproduction of amyloid beta (Abeta) may not be the only pathogenic route to AD. Decreased degradation of Abeta is another possible disease mechanism. Neprilysin is a neutral endopeptidase that has been proposed to be the major enzyme responsible for Abeta degradation. Studies have reported correlations between Abeta deposition and neprilysin activity in the human brain. This study shows that intracerebroventricular infusion of thiorphan, a neprilysin inhibitor, raises cortical and cerebrospinal fluid (CSF) Abeta concentrations in rabbits. Rabbits treated with thiorphan for 5 days had levels of CSF and cortical Abeta40 that were 147 and 142% of the control group, respectively. Results for Abeta42 showed a similar trend. The results indicate that age-related decreases of neprilysin could lead to increased brain concentrations of Abeta, plaque formation, and AD.
Starting Page	178
Ending Page	180
Page Count	3
File Format	PDF HTM / HTML
DOI	10.1016/S0304-3940(03)00902-9
PubMed reference number	14550923
Journal	Medline
Volume Number	350
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0304394003009029
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0304394003009029?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/S0304-3940%2803%2900902-9
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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