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Transmission of Mycoba cterium tuberculosis to households of tuberculosis patients: a comprehensive contact tracing study.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Khalilzadeh, Soheila Masjedi, Heidar Hosseini, Mostafa Safavi, Arash Masjedi, Mohammad-Reza |
| Copyright Year | 2006 |
| Abstract | BACKGROUND Tuberculosis (TB) continues to be a major health problem in developing countries. Contact investigation is the most appropriate strategy to interrupt transmission and subsequent development of TB. METHODS This cross-sectional study was conducted to assess the impact of contact screening on case-finding by using tuberculin skin test chest radiography. Contacts of smear-positive patients with pulmonary TB (index cases) were diagnosed and registered in our center during 2002 - 2004. Contacts, defined as household members living with index cases for >30 days, were screened by sputum examination, tuberculin skin test, and chest radiography. RESULTS Sixty-eight patients with smear-positive pulmonary TB were considered as index cases. A total of 224 close contacts with index cases (an average of 3 contacts for each index case) were detected. Age among contacts ranged from 6 months to 74 years. Eighty-three percent of contacts were Iranians and 17% were Afghans. Abnormal radiographs were seen in 49.6% of contacts. Sixteen point five percent of contacts had a positive tuberculin skin test of >10 mm; 7.6% had a positive sputum smear. The mean +/- SD age of Iranian contacts (29.1 +/- 16.6 years) was significantly (P < 0.001) higher than that of Afghans (18.6 +/- 14.1 years). Cavitary formation, nodular pattern, and infiltration were found to have a strong association with a positive sputum smear for acid fast bacilli (100%, 100%, and 87%, respectively). CONCLUSION The rate of TB in contacts was higher than other similar studies. Earlier detection and treatment of adults with TB could interrupt transmission and be a step towards eliminating childhood TB. Contact control and source-case investigations should be emphasized for TB control. Novel strategies are needed to maximize the number of contacts who are not only identified and evaluated, but also completely treated. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 16859052 |
| Journal | Medline |
| Volume Number | 9 |
| Issue Number | 3 |
| Alternate Webpage(s) | http://www.ams.ac.ir/AIM/NEWPUB/06/9/3/007.pdf |
| Alternate Webpage(s) | http://www.tums.ac.ir/1394/04/29/Original%20Article.pdf-hoseinim-2015-07-20-09-06.pdf |
| Journal | Archives of Iranian medicine |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
