NDLI: Diallyl disulfide inhibits the metastasis of type Ⅱ esophageal‑gastric junction adenocarcinoma cells via NF-κB and PI3K/AKT signaling pathways in vitro.

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Diallyl disulfide inhibits the metastasis of type Ⅱ esophageal‑gastric junction adenocarcinoma cells via NF-κB and PI3K/AKT signaling pathways in vitro.

Content Provider	Semantic Scholar
Author	Yin, Xiaoran Feng, Cheng Han, Lili Ma, Yinan Jiao, Yang Wang, Jun Jia, Lijun Jing, Fuchun Gao, Xiaoyan Zhang, Yinbin Zhang, Jun
Copyright Year	2018
Abstract	Esophageal-gastric junction adenocarcinoma (AEG) is an aggressive tumor with high incidence and dismal prognosis worldwide. Despite significant advances in therapeutic strategies, the 5-year survival rate still remains low. Diallyl disulfide (DADS), which is one of the major volatile components isolated from garlic, has been shown to have multi-targeted antitumor activities in a variety of cancer cells. However, the exact anti-metastatic effects and underlying molecular mechanisms of DADS in AEG have not been elucidated. The present study demonstrated that DADS inhibited cell viability of OE19 cells with low cytotoxicity to healthy hepatocytes, L02 cells, in vitro. Non-toxic doses of DADS were ≤10 µg/ml for a 24-h treatment. Our data showed that these non-toxic doses of DADS were found to block the metastasis of OE19 cells by suppressing MMPs, increasing u-PA and TIMPs, as well as altering the balance of MMPs/TIMPs, which at least in part resulted from the suppression of NF-κB and PI3K/AKT signaling pathways. The present study provides a previously neglected insight into the investigation of DADS in suppressing tumor metastasis and its underlying molecular mechanisms in vitro. Hence, DADS could be a promising anticancer agent for anti-metastatic treatment of AEG in the future.
Starting Page	784
Ending Page	794
Page Count	11
File Format	PDF HTM / HTML
DOI	10.3892/or.2017.6113
PubMed reference number	29207122
Journal	Medline
Volume Number	39
Issue Number	2
Journal	Oncology reports
Alternate Webpage(s)	https://www.spandidos-publications.com/or/39/2/784/download
Alternate Webpage(s)	https://doi.org/10.3892/or.2017.6113
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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