NDLI: Higher Frequency of CD4+CXCR5+ICOS+PD1+ T Follicular Helper Cells in Patients With Infectious Mononucleosis

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Higher Frequency of CD4+CXCR5+ICOS+PD1+ T Follicular Helper Cells in Patients With Infectious Mononucleosis

Content Provider	Semantic Scholar
Author	Liu, Jinlin Zhou, Yong-Lie Yu, Qinghua Zhao, Zhao Wang, Huan Luo, Xiaoming Chen, Yanxia Zhu, Zhongliang Chen, Guoqing Qiu, Liannv
Copyright Year	2015
Abstract	AbstractFollicular helper T (Tfh) cells are recognized as a distinct CD4+helper T cell subset, and mainly dysregulated in the autoimmune disease, whether it plays a role in the infectious mononucleosis (IM) diseases is unknown. In this study, we found that the CD4+CXCR5+ Tfh cells were not significantly changed, but the CD4+CXCR5+ICOS+ and CD4+CXCR5+ICOS+PD1+ Tfh subsets were significantly increased in the IM patients, and all these cells were significantly changed after antiviral therapy. Second, only the numbers of CD4+CXCR5+ICOS+PD1+ Tfh cells correlated with the Epstein-Barr virus (EBV) DNA load, negatively correlated with the numbers of naive B cells and amount of IL-21, and positively correlated with the numbers of plasma cells, memory B cells, and atypical lymphocytes. Third, the frequency of CD4+CXCR5+ICOS+PD1+ Tfh subset was significantly higher in lymphadenectasis or hepatosplenomegaly patients, and associated with the level of alanine aminotransferase (ALT). All together, our findings discovered this CD4+CXCR5+ICOS+PD1+ Tfh cell subset might play an important role in the pathogenesis of IM.
File Format	PDF HTM / HTML
DOI	10.1097/MD.0000000000002061
PubMed reference number	26559315
Journal	Medline
Volume Number	94
Alternate Webpage(s)	https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/15/10/medi-94-e2061.PMC4912309.pdf
Alternate Webpage(s)	https://doi.org/10.1097/MD.0000000000002061
Journal	Medicine
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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