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Synthetic and kinetic investigations into living free-radical polymerisation used in the preparation of polymer therapeutics
| Content Provider | Semantic Scholar |
|---|---|
| Author | Adash, Uma |
| Copyright Year | 2006 |
| Abstract | 2 CHAPTER ONE. INTRODUCTION 4 1.1 LIVING FREE-RADICAL POLYMERISATION 4 1.1.1 BACKGROUND 4 1.1.2 THE PARADIGM OF LIVING FREE-RADICAL POLYMERISATION 7 1.1.3 ATRP – ATOM TRANSFER RADICAL POLYMERISATION 9 1.1.3.1 Initiator 10 1.1.3.2 Monomer 10 1.1.3.3 Ligand (L) 11 1.1.3.4 Solvent 12 1.1.4 KINETICS AND MOLECULAR WEIGHTS 12 1.1.5 RAFT – REVERSIBLE ADDITION-FRAGMENTATION (CHAIN) TRANSFER POLYMERISATION 14 1.1.6 MACROMOLECULAR DESIGN 16 1.2 POLYMER THERAPEUTICS 18 1.2.1 CANCER 19 1.2.1.1 History and nature of the disease 19 1.2.1.2 Current methods of treatment 19 1.2.1.3 Polymer therapeutics 20 1.3 THIS THESIS 24 1.3.1 AIMS AND RATIONALE 24 1.3.2 OUTLINE 27 1.4 REFERENCES 27 CHAPTER TWO. EXPERIMENTAL DETAILS 30 2.1 GENERAL EXPERIMENTAL 30 2.2 POLYMERISATION 31 2.3 SYNTHESES 31 2.3.1 N-(N-PENTYL)-2-PYRIDYLMETHANIMINE (PEN) 31 2.3.2 COPPER (I) BROMIDE 32 2.3.3 HYDROXYETHYL 2-BROMOISOBUTYRATE (HEBISOB) 32 2.3.4 METHACRYLOYL CHLORIDE (MAC) 33 2.3.5 METHACRYLOYLOXY SUCCINIMIDE (MAOS) 33 2.3.6 N-(2-HYDROXYPROPYL)METHACRYLAMIDE (HPMA) 34 2.3.7 P-NITROPHENYL METHACRYLATE (NPMA) 35 2.3.8 BIS(DITHIOBENZOYL) DISULFIDE 36 2.3.9 2-(2-CYANOPROPYL)DITHIOBENZOATE 37 2.3.10 4,4’-AZOBIS(CYANOPENTANOL) 37 2.3.11 DITHIOBENZOIC ACID 1-CYANO-4-HYDROXY-1-METHYL-BUTYL ESTER 38 2.3.12 4-CYANOPENTANOIC ACID DITHIOBENZOATE 39 2.3.13 TRIPHENYLMETHYL DITHIOBENZOATE 39 2.3.14 N-METHACRYLOYLGLYCYLGLYCINE P-NITROPHENYL ESTER (MA-GLY-GLY-ONP) 40 2.4 INSTRUMENTAL 42 2.4.1 GEL PERMEATION CHROMATOGRAPHY 42 2.4.1.1 Ian Wark Laboratories, CSIRO, Melbourne 42 2.4.1.2 Key Centre for Polymer Colloids, University of Sydney 42 2.4.1.3 Polymer Institute of the Slovak Academy of Sciences, Bratislava 43 2.4.2 NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (NMR) 43 2.4.3 HIGH RESOLUTION MASS SPECTROMETRY 43 2.5 REFERENCES 44 CHAPTER THREE. ATOM TRANSFER RADICAL POLYMERISATION – ATRP 45 3. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://ir.canterbury.ac.nz/bitstream/handle/10092/1282/thesis_fulltext.pdf?isAllowed=y&sequence=1 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
