Loading...
Please wait, while we are loading the content...
Similar Documents
Enhancement of prepulse inhibition after blockade of GABA activity within the superior colliculus
| Content Provider | Semantic Scholar |
|---|---|
| Author | Fendt, Markus |
| Copyright Year | 1999 |
| Abstract | The present study examined the effects of local microinjections of the GABA chloride channel blocker Picrotoxin into the superior colliculus (SC) on prepulse inhibition (PPI) of the acoustic startle response (ASR) in rats. PPI is a useful model for the investigation of the neuronal basis of sensorimotor gating which is deficient in some psychiatric disorders, such as schizophrenia. Blockade of GABA activity within the SC by Picrotoxin injections (leading to a moderate stimulation of the SC) significantly enhanced PPI without affecting the ASR baseline amplitude or the spontaneous motor activity. Based on these results we discuss the role of the SC in a hypothetical neuronal circuit mediating PPI of the ASR. |
| Starting Page | 81 |
| Ending Page | 85 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0006-8993(99)01525-5 |
| PubMed reference number | 10375679 |
| Journal | Medline |
| Volume Number | 833 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0006899399015255 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0006899399015255?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S0006-8993%2899%2901525-5 |
| Journal | Brain Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
