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Tiagabine-induced absence status in idiopathic generalized epilepsy
| Content Provider | Semantic Scholar |
|---|---|
| Author | Knake, S. Hamer, Hajo M. Schomburg, Uwe Oertel, Wolfgang Hermann Rosenow, F. |
| Copyright Year | 1999 |
| Abstract | Several medications such as baclofen, amitriptyline and even antiepileptic drugs such as carbamazepine or vigabatrin are known to induce absence status epilepticus in patients with generalized epilepsies. Tiagabine (TGB) is effective in patients with focal epilepsies. However, TGB has also been reported to induce non-convulsive status epilepticus in several patients with focal epilepsies and in one patient with juvenile myoclonic epilepsy. In animal models of generalized epilepsy, TGB induces absence status with 3-5 Hz spike-wave complexes. We describe a 32-year-old patient with absence epilepsy and primary generalized tonic-clonic seizures since 11 years of age, who developed her first absence status epilepticus while treated with 45 mg of TGB daily. Administration of lorazepam and immediate reduction in TGB dosage was followed by complete clinical and electroencephalographic remission. This case demonstrates that TGB can induce typical absence status epilepticus in a patient with primary generalized epilepsy. |
| Starting Page | 314 |
| Ending Page | 317 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://core.ac.uk/download/pdf/82366734.pdf |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S1059131199903035 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S1059131199903035 |
| PubMed reference number | 10486298v1 |
| Alternate Webpage(s) | https://doi.org/10.1053/seiz.1999.0303 |
| DOI | 10.1053/seiz.1999.0303 |
| Journal | Seizure |
| Volume Number | 8 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Amitriptyline Baclofen Carbamazepine Childhood Absence Epilepsy Epilepsies, Myoclonic Epilepsies, Partial Epilepsy, Generalized Idiopathic generalized epilepsy Lorazepam Myoclonic Epilepsy, Juvenile Parasitic Diseases, Animal Patients Seizures, Clonic Status Epilepticus Tonic - clonic seizures Tonic-Clonic Epilepsy Vigabatrin tiagabine |
| Content Type | Text |
| Resource Type | Article |
