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Dietary rapeseed/canola-oil supplementation reduces serum lipids and liver enzymes and alters postprandial inflammatory responses in adipose tissue compared to olive-oil supplementation in obese men.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kruse, Michael J. Loeffelholz, Christian Von Hoffmann, Daniela Stevanin Pohlmann, Antje Seltmann, Anne-Cathrin Osterhoff, Martin Hornemann, Silke Pivovarova, Olga Vladimirovna Rohn, Sascha Jahreis, Gerhard Pfeiffer, Andreas F. H. |
| Copyright Year | 2015 |
| Abstract | SCOPE Obesity is associated with hyperlipidemia, hepatic steatosis, and low-grade inflammation. Studies have shown that MUFA as well as PUFA have beneficial effects on blood lipids and the inflammatory state. METHODS AND RESULTS This study investigates the effects of a daily supplementation of either 50 g of rapeseed/canola (RA) or olive (OL) oil over 4 wk on serum lipids, serum liver enzymes, and inflammatory gene expression in subcutaneous (s. c.) adipose tissue in obese men. Consuming RA resulted in increased serum n-3 fatty acids and a reduction in total cholesterol, LDL cholesterol, and serum aspartate aminotransferase compared to OL. In s. c. adipose tissue, gene expression of the pro-inflammatory cytokine IL6 was reduced in RA compared to OL. However, after 4 h after a test meal, containing the appropriate oil, white bread, and 400 mL of liquid diet drink (835 kcal in total), gene expression of IL6, IL1B, and EMR1 (egf-like module containing Mucin-like hormone receptor-like 1) was increased in RA and of monocyte chemoattractant protein-1 (CCL2) in both RA and OL. CONCLUSION This demonstrates that consuming RA for 4 wk improves serum lipids, liver enzymes, and basal inflammation in s. c. adipose tissue, but it mediates an acute pro-inflammatory response in adipose tissue upon consuming a meal. |
| Starting Page | 7897 |
| Ending Page | 7908 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.waggapure.com/pdf/diabetes/Diabetes_4.pdf |
| PubMed reference number | 25403327v1 |
| Alternate Webpage(s) | https://doi.org/10.1002/mnfr.201400446 |
| DOI | 10.1002/mnfr.201400446 |
| Journal | Molecular nutrition & food research |
| Volume Number | 59 |
| Issue Number | 3 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adipose tissue Aspartate Transaminase Aspartic Acid Brassica rapa Chemotactic Factors Cholesterol Fatty Acids, Monounsaturated Gene Expression Hematological Disease Hormone Receptor Hyperlipidemia Inflammation Lipids Liquid diet Measurement of serum lipid level Obesity Olives - dietary Omega-3 Fatty Acids Polyunsaturated Fatty Acids Steatohepatitis canola oil cytokine inflammatory response kilocalorie |
| Content Type | Text |
| Resource Type | Article |
