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Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neurons.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kang, Ning Jiang, Li Nedergaard, Maiken Kang, Jian |
| Copyright Year | 2005 |
| Abstract | The efficiency of neural circuits is enhanced not only by increasing synaptic strength but also by increasing intrinsic excitability. In contrast to the detailed analysis of long-term potentiation (LTP), less attention has been given to activity-dependent changes in the intrinsic neuronal excitability. By stimulating hippocampal CA1 pyramidal neurons with synaptic inputs correlating with postsynaptic neuronal spikes, we elicited an LTP of intrinsic excitability (LTP-IE) concurring with synaptic LTP. LTP-IE was manifested as a decrease in the action potential threshold that was attributable to a hyperpolarized shift in the activation curve of voltage-gated sodium channels (VGSCs) rather than activity-dependent changes in synaptic inputs or A-type K+ channels. Cell-attached patch recording of VGSC activities indicated such an activity-dependent change in VGSCs. Induction of LTP-IE was blocked by the NMDA receptor antagonist APV, intracellular BAPTA, the CaM kinase inhibitors KN-62 and autocamtide-2-related inhibitory peptide, and the protein synthesis inhibitors emetine and anisomycin. The results suggest that induction of LTP-IE shares a similar signaling pathway with the late phase of synaptic LTP and requires activation of the NMDA glutamate receptor subtype, Ca2+ influx, activity of CaM kinase II, and function of the protein synthesis. This new form of hippocampal neuronal plasticity could be a cellular correlate of learning and memory besides synaptic LTP. |
| File Format | PDF HTM / HTML |
| DOI | 10.1523/JNEUROSCI.4217-04.2005 |
| PubMed reference number | 15716411 |
| Journal | Medline |
| Volume Number | 25 |
| Issue Number | 7 |
| Alternate Webpage(s) | http://www.jneurosci.org/content/jneuro/25/7/1750.full.pdf |
| Alternate Webpage(s) | http://diyhpl.us/~bryan/papers2/neuro/ion-channel-journal-club/Activity-dependent%20LTP%20of%20intrinsic%20excitability%20in%20hippocampal%20CA1%20pyramidal%20neurons.pdf |
| Alternate Webpage(s) | https://doi.org/10.1523/JNEUROSCI.4217-04.2005 |
| Journal | The Journal of neuroscience : the official journal of the Society for Neuroscience |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
