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α1- and α2-adrenergic receptors in rat corpus striatum
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sebben-Perez, M. Ebersolt, C. Blanc, Ge´rard Bockaert, Joe¨l |
| Copyright Year | 1984 |
| Abstract | Rat corpus striatum contained ?(2)-adrenergic receptor which were labelled with [(3)H]clonidine (95 +/- 6 fmol/mg protein). The affinity of these receptors (K(d) = 1.3 to 3.6 nM) was similar to that found in cerebral cortex. Five days after kainic lesions, the number of ?(2)-adrenergic receptors had dropped by half, suggesting that their location might be neuronal. One month after lesions, the number of ?(2)-adrenergic receptors had risen to that of the controls and was higher after two months. This increase would suggest a glial localization of the ?(2)-adrenergic receptor. We have previously described the presence of ?(2)-adrenergic receptors in primary astrocyte cultures (Ebersolt et al., 1981). Rat corpus striatum contained less ?(1)-adrenergic receptors than ?(2)-adrenergic receptors. They were labelled with [(3)H]prazosin (28 +/- 1.9 fmol/mg protein) and were only slightly altered 5 days after kainic acid lesions (?20%). In addition to these classical ?(1)-adrenergic receptors, rat corpus striatum also contained [(3)H]WB4101 binding sites having high affinity for WB4101 (2-5 nM) and norepinephrine (1 ?M) but a very low affinity for prazosin (4.4 ?M). The exact nature of these sites remains unknown. |
| Starting Page | 103 |
| Ending Page | 108 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0197-0186(84)90033-0 |
| PubMed reference number | 20488027 |
| Journal | Medline |
| Volume Number | 6 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0197018684900330 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0197018684900330?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0197-0186%2884%2990033-0 |
| Journal | Neurochemistry International |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
