NDLI: Transcriptional control of the HERV-H LTR element of the GSDML gene in human tissues and cancer cells

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Transcriptional control of the HERV-H LTR element of the GSDML gene in human tissues and cancer cells

Content Provider	Semantic Scholar
Author	Kang, Dae Woo Lee, S.-Y. Sik-Yum
Copyright Year	2006
Abstract	Summary.Long terminal repeats (LTRs) of human endogenous retroviruses (HERVs) have been reported to serve as alternative promoters in functional genes. The GSDML (gasdermin-like protein) gene located on human chromosome 17q21 has been found to be an oncogenomic recombination hotspot. Here, we identified the LTR element of HERV-H with reverse orientation as an alternative promoter of the GSDML gene and analyzed its expression pattern in human tissues and cancer cells. A reporter gene assay of the promoter activity of the LTR on the GSDML gene in human cancer cell lines (HCT-116 and HeLa) and a kidney cell line (Cos7) of African green monkey indicated that the LTR promoter with reverse orientation had stronger promoter activity than forward one. The transcripts of this LTR-derived promoter were widely distributed in various human tissues and cancer cells, whereas the transcripts of the cellular promoter were found only in stomach tissues and some cancer cells (HCT116, MCF7, U937, C-33A, and PC3). These findings suggest that the LTR element on the GSDML gene was integrated into the hominoid lineage and acquired the role of transcriptional regulation of human tissues and cancer cells.
Starting Page	1985
Ending Page	1994
Page Count	10
File Format	PDF HTM / HTML
DOI	10.1007/s00705-006-0764-5
PubMed reference number	16625320
Journal	Medline
Volume Number	151
Alternate Webpage(s)	https://page-one.springer.com/pdf/preview/10.1007/s00705-006-0764-5
Journal	Archives of Virology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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