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Peptidylglycine α-amidating monooxygenase activity in spinal cord, dorsal roots, and dorsal root ganglia ofMacaca fascicularis
| Content Provider | Semantic Scholar |
|---|---|
| Author | Graham, Lila Gallop, Paul M. |
| Copyright Year | 1989 |
| Abstract | Abstract Several peptides synthesized by primary sensory neurons are α-amidated at the C-terminal residue, including vasoactive intestinal polypeptide, neurokinin A and substance P, which is also abundant in spinal cord. In pituitary and other tissues, the C-terminal amidation is catalyzed by peptidylglycine α-amidating monooxygenase (PAM). In the present study, soluble PAM activity in spinal cord and in primary sensory neurons is quantified and characterized as to cofactor and cosubstrate requirements and substrate specificity. |
| Starting Page | 371 |
| Ending Page | 373 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0006-8993(89)90073-5 |
| Volume Number | 491 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0006899389900735 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0006899389900735?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0006-8993%2889%2990073-5 |
| Journal | Brain Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
