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Expression and prognostic significance of LIVIN, SURVIVIN and other apoptosis-related genes in the progression of superficial bladder cancer.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gazzaniga, Pier Paolo Gradilone, Angela Giuliani, Laura Gandini, Orietta Silvestri, Ida Nofroni, Italo Saccani, Graziella Frati, Luigi Aglianò, Anna Maria |
| Copyright Year | 2003 |
| Abstract | BACKGROUND It has been suggested that progression of superficial bladder cancer may be regulated at the molecular level by a typical pattern of expression of genes involved in apoptosis. Recently LIVIN, belonging to the inhibitors of apoptosis (IAP) family, has been found to be expressed in most solid tumors, where its expression is suggested to have prognostic significance. No data are available concerning the significance of LIVIN in the progression of bladder tumors. PATIENTS AND METHODS In the present paper we used RT-PCR to investigate the expression of LIVIN isoforms alpha and beta, SURVIVIN, BCL-X and BCL-2/BAX expression ratio both in normal and tumoral bladder tissues, and correlated their expression with the emergence of early relapses in a follow-up of 4 years. This study shows that only the alpha isoform of LIVIN, which is not expressed in normal bladder tissue, is expressed in a proportion of tumors with a high risk of relapse. RESULTS LIVIN was found in 7/30 patients (23%), SURVIVIN in 9/30 (30%), BCL-2/BAX ratio >1 in 16/30 (53%), BCL-2/BAX expression ratio <1 in 14/30 (46.6%) and BCL-X, only in isoform BCL-X(L), in 11/30 (36.6%). When we evaluated the dependence between each gene expression and relapse free time of patients, we found that LIVIN, high BCL-2/BAX ratio and BCL-X(L), but not SURVIVIN, reached statistical significance in order to predict relapses. CONCLUSIONS Our findings suggest that LIVIN may be involved in the progression of superficial bladder cancer and used as a marker of early recurrence; while the expression of SURVIVIN cannot be used to identify patients with high risk of relapse. |
| Starting Page | 85 |
| Ending Page | 90 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://watermark.silverchair.com/mdg002.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAABBwwggQYBgkqhkiG9w0BBwagggQJMIIEBQIBADCCA_4GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMJLjNMbt7aEE8USKjAgEQgIIDz82r1toMH9miiHPH2d6zgAS4kuc_YIbuocJ-7fKSos3thLZyAq4sGuYm4vVBFc32ZYGCbip8_l6LPTtNsXDVb67DwSs6UZIaVdNOWUI5vV43rh2XNkaKWjNwpaA1vvJihFhdQB3IrX08I-OzqBJAjwbHE-zScTq5o43EM7SeeQ5vA3ltIt1sANyw4AuuuJp5lO5iFxqbrQqcXWhl2yHbn7Kj22CerfGbmkJQ8ymJbBlCIeZSncIBy7oNujEaDOf5nfmWJ5TqWhYNvLIn698JN1kcCEDOkznP7w9c9ea_2zKjvEX_Pj1hoZ7Qh3EslH9agoAEQ_q42ybL4ltvsviqDbmIAEEIC3KwVxwrjcMOeAPjfHLjg7NlJ2k19lHdbWyEC9zSXaWvicsNK3yrnoFt5yo7yyG7J6_gHzV0NqFz9dyqZ3vL51FIUJBguzjASpjtxBFblT-BDYdO1GLB0luG5FaAiDO7srx9C0od3NN8BqGikkHOpuT4rsgXAPUY6nGMinVWsiLDFKxw1dDI3tI51wKtILbHblklHXG4k8fi43N8N24_X6E_NsEjx0rirpylO5Va888WSv3eS95Vs_7Ff1TNyEFP8r_QMc8-5u2t3rCQQto2rzTo0SSqocjWgM_ynBn7_YQVKRzyQUzwSqAvuNSq33XnEyxivoqOFkDT6ZwL8UzgK9psKwuKJTWBGLU75m3wxRdzH96nQXzOCDr80yllb-qAAHkTB8Nf13xDPWf_03KoUlRtXncxT9vSfJQi1Q4lbsKBIF57CnTqE9Hr85_ADYiBuSBgD78l9mV25WhIO05rCFpgugYthLqO-_G9lrmhcRIqWULZjbv1KTN-f6ypvSRL-y0xMMELcmGkdN-j2uTE5yGki_bcAkR8YX-5jHVXDRRzcWOnPqxPdMM6Y1H8xgAtv2Hc-j7nXEwaY8r9xVcfImn3wQbhjy_7GWMEB8257H0qHu-ZawKNmwl3gFgpt7ixSI9J0HEElLdc0og0htmeyqu2kf059HWXc7Qm3vhdn5HcrvI_2YK8Ovw-bmXGWlYVU6YuypDznUOb_QWmBp8TK8f7sQaf9WDYVUafua1H_Z66FWnO1bCGEZC2txQQuiRxmemVauovacIqMVCkiAydcfhtfrWgfXDzX526rwZXQEIIp93MIghhpLbSn82Geub4b4xOr9L5ToqbLsWe2LmCsz6HaRxg-CUKWKelbgzl9sdNindaWw-51oZqDM864qCu0KUyTF69poziA0ov9wHegqxHOUVT1YKs8L3gSjo-Cy6vepL3uE7AYwdrtg |
| Alternate Webpage(s) | http://annonc.oxfordjournals.org/content/14/1/85.full.pdf |
| PubMed reference number | 12488298v1 |
| Volume Number | 14 |
| Issue Number | 1 |
| Journal | Annals of oncology : official journal of the European Society for Medical Oncology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Apoptosis B-Cell Lymphoma 6 Protein BCL-XL Protein BIRC7 wt Allele Bladder Neoplasm Bladder Tissue Body tissue Gene Expression Neoplasms P-Value Patients Protein Isoforms Superficial Bladder Carcinoma solid tumor |
| Content Type | Text |
| Resource Type | Article |
