NDLI: Prognostic significance of estrogen receptor, progesterone receptor, HER2/neu, Ki-67, and nm23 expression in patients with invasive breast cancer.

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Prognostic significance of estrogen receptor, progesterone receptor, HER2/neu, Ki-67, and nm23 expression in patients with invasive breast cancer.

Content Provider	Semantic Scholar
Author	Çubukçu, Erdem Kanat, Ozkan Olmez, Omer Fatih Kabul, Selva Canhoroz, Mustafa Avci, Nilufer Deligonul, Adem Hartavi, Mustafa Çubukçu, Sinem Olmez, Fatma Kurt, E. Evrensel, Turkkan Gokgoz, Sehsuvar Manavoğlu, Osman
Copyright Year	2013
Abstract	PURPOSE To determine the prognostic significance of estrogen receptor (ER), progesterone receptor (PR), HER2/neu, Ki-67, and nm23 immunohistochemical expression with respect to progression free survival (PFS) and overall survival (OS) in Turkish patients with invasive breast cancer (IBC). METHODS Patients with IBC (n = 81; mean age = 51.9 ± 11.1 years) were prospectively enrolled at the Department of Oncology, Uludag University Medical Center, Bursa, Turkey. Immunohistochemistry was performed on formalin- fixed, paraffin-embedded tissue sections. RESULTS We did not find any significant association between immunohistochemical expression of ER, PR, HER2/ neu, Ki-67, and nm23 and the baseline characteristics of IBC patients. The median patient PFS was 30 months (range 22-45), and the median OS was 32 months (range 23-46). Stratification of the patient population according to nm23 immunohistochemical expression revealed a statistically significant difference in terms of both OS (p < 0.05) and DFS (p < 0.05). Multivariate Cox regression analysis indicated that tumor grade, axillary lymph node status, and nm23 immunohistochemical expression were the 3 main independent prognostic factors for PFS and OS in IBC patients. CONCLUSION Reduced nm23 immunohistochemical expression is an independent negative prognostic factor for OS and PFS. Patients with negative nm23 expression may require a more intensive follow-up.
File Format	PDF HTM / HTML
PubMed reference number	23818346
Journal	Medline
Volume Number	18
Issue Number	2
Alternate Webpage(s)	http://www.jbuon.com/pdfs/359-365-Cubukcu.pdf
Journal	Journal of B.U.ON. : official journal of the Balkan Union of Oncology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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