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Persistent wheezing in infants with an atopic tendency responds to inhaled fluticasone.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chavasse, Richard J. P. G. Bastian-Lee, Yvonne Richter, Henning Hilliard, Tandrea Seddon, Patricia Gawlik |
| Copyright Year | 2001 |
| Abstract | BACKGROUND The role of inhaled corticosteroids for the treatment of wheeze in infancy remains unclear. AIM To investigate the effect of inhaled fluticasone on symptoms in a group of wheezy infants who had a high risk of progressing to childhood asthma. METHODS A total of 52 infants, under 1 year of age, with a history of wheeze or cough and a history (personal or first degree relative) of atopy were prescribed either 150 microg fluticasone twice daily (group F) or placebo (group P), via metered dose inhaler, for 12 weeks following a two week run in period. Symptoms were scored in a parent held diary and the mean daily symptom score (MDS) and symptom free days (SFD) calculated for each two week period. RESULTS Thirty seven infants completed the study. Both MDS and SFD improved significantly between the run in and final two week period in group F, but not group P, with a mean difference in change (95% CI) between groups of 1.12 (0.05 to 2.18) for MDS and median difference of 3.0 (0.002 to 8.0) for SFD. CONCLUSION Improvement of clinical symptoms in response to fluticasone can be shown in this high risk group of infants. In the absence of effective alternatives inhaled corticosteroids should be considered in this patient group. |
| Starting Page | 8 |
| Ending Page | 11 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://pediatrics.aappublications.org/content/pediatrics/110/Supplement_2/461.3.full.pdf |
| Alternate Webpage(s) | http://pediatrics.aappublications.org/content/pediatrics/110/Supplement_2/461.1.full.pdf |
| Alternate Webpage(s) | http://pediatrics.aappublications.org/content/pediatrics/110/Supplement_2/461.2.full.pdf |
| Alternate Webpage(s) | http://adc.bmj.com/content/archdischild/85/2/143.full.pdf |
| PubMed reference number | 11466189v1 |
| Volume Number | 85 |
| Issue Number | 2 |
| Journal | Archives of disease in childhood |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adrenal Cortex Hormones Atopy Coughing Fluticasone Propionate, Salmeterol Xinafoate Drug Combination Inhaler Inspiration function Patients Respiratory Sounds Score Wheezing childhood asthma |
| Content Type | Text |
| Resource Type | Article |
