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Efficacy of intravenous iron therapy in non-anaemic iron-deficient patients with fatigue.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Arcani, Robin Suchoń, Paweł Venton, Geoffroy Soubrier, C. Gaigne, L. Doddoli, Suchitra Koubi, May Brandejsky, Laura Swiader, Lawrence Veit, Véronique Jean, E. Harle, J.-R. Durand, J-M |
| Copyright Year | 2020 |
| Abstract | Iron deficiency, without anaemia, is common in the general population and induces various symptoms. Its management consists of oral and intravenous supplementation for cases of inefficacy of or intolerance to oral iron. We assessed the efficacy of intravenous iron therapy in non-anaemic iron-deficient patients with fatigue. We prospectively evaluated the level of fatigue, using the Fatigue Severity Scale (FSS), in patients suffering from iron deficiency without anaemia, treated by intravenous iron at the moment of the perfusion (W0), after 4 weeks (W4), and 12 weeks (W12). Of 25 patients, at W0, the mean FFS was 49.3+/-13.7. There was a significant improvement in FSS at W4 (44+/-15; p = 0.01) and a sustained response at W12 with an FFS of 35.8+/-17.1 (p < 0,0001). There was no correlation between FSS and serum ferritin level at W12 (p=0.54) or between serum ferritin at W12 and difference between FSS at W0 and W12 (p=0.58). There were six mild adverse events (24%): asthenia (8%), nausea (8%), headache (4%), local pain (4%); and no serious adverse events. Our results suggest the rapid efficacy of intravenous iron in improving fatigue in iron deficiency without anaemia with a good profile of tolerance. |
| Starting Page | 34 |
| Ending Page | 36 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 32043476 |
| Journal | Medline |
| Volume Number | 78 |
| Issue Number | 1 |
| Alternate Webpage(s) | http://www.njmonline.nl/getpdf.php?id=232&t=i |
| Alternate Webpage(s) | http://njmonline.nl/getpdf.php?id=2182 |
| Journal | The Netherlands journal of medicine |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
