[Clinical study on idiopathic thrombocytopenic purpura treated with Shengxueling Granule].

Content Provider	Semantic Scholar
Author	Zhou, Yong-Ming Hu, Ming-Hui Yang, Jing-Ming Zhu, Wen-Wei Huang, Zhen-Qiao Zhou, Shao-Hong Lu, Jia-Hui
Copyright Year	2004
Abstract	OBJECTIVE To observe the clinical effect of Shengxueling Granule (SXLG) in treating idiopathic thrombocytopenic purpura (ITP), and to study its possible mechanism. METHODS Eighty-six cases of ITP were divided into two groups randomly. Fifty-six cases in the treatment group were treated with SXLG, a traditional Chinese medicine, and 30 cases administered with Western medicine (prednisone) were taken as control. Patients in each group took drugs for three months and were under follow-up observation. RESULTS In SXLG-treated group, the total effective rate in 3 months was 85.71%, similar to 83.33% in prednisone-treated group (P>0.05), while the total effective rate in 6 months in the SXLG-treated group was 91.07%, higher than 53.33% of the prednisone-treated group (P<0.01), and no obvious side-effects were observed. The patients' bleeding was alleviated or stopped, and their general condition was improved. And the blood platelet count (BPC) was increased, the platelet associated immunoglobulin (PAIg) and interleukin-4 (IL-4) were markedly dropped, the level of natural killer cells activity (NKCA) increased, and the rate of T lymphocyte subsets gradually returned to normal level. Megakaryocytes tended toward maturation on bone marrow smear after SXLG treatment. All differences above were statistically significant. CONCLUSION SXLG is an effective and safe medicine for ITP. It can regulate the cellular immunity, inhibit the platelet antibody to reduce the destruction of the platelet and to increase the number of platelet, promote the differentiation and maturation of megakaryocyte, facilitate the production and release of platelet, lower the fragility of capillary, and prevent the hemorrhagic tendency.
Starting Page	1881
Ending Page	1883
Page Count	3
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.jcimjournal.com/articles/publishArticles/pdf/2006323261883821.pdf
PubMed reference number	15539017v1
Volume Number	2
Issue Number	6
Journal	Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
Language	English
Access Restriction	Open
Subject Keyword	Anatomical maturation Biologic Development Blood Platelet Disorders Blood Platelets Bone Marrow Smear Cellular Immunity Dropping Follow-Up Report Gastrointestinal Hemorrhage Immune thrombocytopenic purpura Inosine Triphosphate Lymphocyte Subset Magnesium Sulfate 1000 MG Oral Granules Megakaryocytes Natural Killer Cell Count Patients Platelet Count measurement Prednisone Recombinant Interleukin-4 Smear - instruction imperative
Content Type	Text
Resource Type	Article