NDLI: Automatic determination of left ventricular ejection fraction from gated blood-pool tomography.

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Automatic determination of left ventricular ejection fraction from gated blood-pool tomography.

Content Provider	Semantic Scholar
Author	Vanhove, Christian Franken, Philippe R. Defrise, Michel Momen, Aa. Everaert, Hendrik Bossuyt, Axel
Copyright Year	2001
Abstract	UNLABELLED The aim of this study was to develop and validate a new algorithm to automatically compute left ventricular ejection fraction (LVEF) from gated blood-pool tomography (GBPT). The results were compared with those of conventional planar radionuclide angiocardiography (PRNA). METHODS Fifty-three consecutive patients received an injection of 740 MBq (99m)Tc-labeled human serum albumin. PRNA and GBPT were performed consecutively in a random sequence. PRNA served as the reference, and GBPT images were processed using a new edge detection algorithm. The algorithm is fast (<45 s), fully automatic, and works in three-dimensional space. The method includes identification of the valve plane and the septum. The left ventricular cavity at end-diastole is delineated by segmentation using an iterative threshold technique. An optimal threshold is reached when the corresponding isocontour best fits the first derivative of the end-diastolic count distribution in three dimensions. This optimal threshold is then applied to delineate the left ventricular cavity on the other time bins. The data are corrected for the partial-volume effect. Left ventricular volumes are determined using a geometry-based method and are used to calculate the ejection fraction. RESULTS The success rate of the new algorithm was 94%. LVEFs calculated from GBPT agreed well with those calculated from PRNA (r = 0.78; GBPT = 0.94 PRNA + 6.33). The systematic error was 2.8%, and the random error was 8.8%. Excellent inter- and intraobserver reproducibility was found, with average differences of 1.1% +/- 4.6% and 1.1% +/- 5.0%, respectively, between the two measurements. CONCLUSION This new algorithm provides a fast, automated, and objective method to calculate LVEF from GBPT.
File Format	PDF HTM / HTML
PubMed reference number	11337514
Journal	Medline
Volume Number	42
Issue Number	3
Alternate Webpage(s)	http://jnm.snmjournals.org/content/42/3/401.full.pdf
Journal	Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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