Effects of antipsychotic drugs on cholecystokinin and preprotachykinin (substance P) mRNA expression in the rat hippocampal formation

Content Provider	Semantic Scholar
Author	Zachrisson, Olof Nomikos, George G. Marcus, Monica M. Svensson, Torgny H. Lindefors, Nils
Copyright Year	2000
Abstract	To assess the involvement of substance P (SP) and cholecystokinin (CCK) in the effects of antipsychotic drugs, preprotachykinin-A (PPT-A) and CCK mRNA expression was studied in the hippocampal formation using in situ hybridisation following 21 daily i.p. injections with the typical antipsychotic drug haloperidol (1 mg/kg) and the atypical drug clozapine (15 mg/kg). PPT-A mRNA levels were increased in the hippocampal CA3 subregion and in the entorhinal cortex after haloperidol, whereas a decrease was observed in the CA1 after clozapine. CCK mRNA levels increased in the CA1, the entorhinal cortex and in hilus, following both haloperidol and clozapine. It is suggested that earlier findings of increased SP levels in the hippocampal formation of schizophrenics may be a consequence of haloperidol treatment and that reduced hippocampal CCK and CCK mRNA levels found earlier in schizophrenics do not result from antipsychotic drug treatment. These results are consonant to the hypothesis that increased cortical CCK transmission may be beneficial in the treatment of psychosis.
Starting Page	355
Ending Page	363
Page Count	9
File Format	PDF HTM / HTML
DOI	10.1016/S0924-977X(00)00093-6
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0924977X00000936
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0924977X00000936?dgcid=api_sd_search-api-endpoint
PubMed reference number	10974607
Alternate Webpage(s)	https://doi.org/10.1016/S0924-977X%2800%2900093-6
Journal	Medline
Volume Number	10
Journal	European Neuropsychopharmacology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article